C₂₃H₁₈N₂O

Base Information

Chemical Name:C₂₃H₁₈N₂O
CAS No.:380918-50-3
Molecular Formula:C₂₃H₁₈N₂O
Molecular Weight:338.409
Hs Code.:

C<sub>23</sub>H<sub>18</sub>N<sub>2</sub>O

Synonyms:C₂₃H₁₈N₂O

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Chemical Property of C₂₃H₁₈N₂O

Chemical Property:

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Technology Process of C₂₃H₁₈N₂O

There total 5 articles about C₂₃H₁₈N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 381248-06-2
3-bromo-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridine-2-one

: 16419-60-6
2-Methylphenylboronic acid

: 380918-50-3
C₂₃H₁₈N₂O

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 6h; Inert atmosphere;
DOI:10.1021/jm301268u

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 380918-50-3
C₂₃H₁₈N₂O

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium; Trimethyl borate / tetrahydrofuran / -75.1 - 20 °C / Inert atmosphere

2: potassium carbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 5.67 h / Reflux

3: hydrogenchloride / water / 3 h / Reflux

4: copper diacetate; pyridine / N,N-dimethyl-formamide / 20 °C

5: N-Bromosuccinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C

6: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

With pyridine; hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Trimethyl borate; copper diacetate; palladium diacetate; potassium carbonate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling / 4: |Ullmann Condensation;
DOI:10.1021/jm301268u

Reference yield:

: 381233-78-9
5-(2-Pyridyl)-1,2-dihydropyridin-2-one

: 380918-50-3
C₂₃H₁₈N₂O

Guidance literature:: Multi-step reaction with 3 steps

1: copper diacetate; pyridine / N,N-dimethyl-formamide / 20 °C

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper diacetate; caesium carbonate; In N,N-dimethyl-formamide; 1: |Ullmann Condensation;
DOI:10.1021/jm301268u