17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid ethyl ester

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Chemical Name:17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl ester
CAS No.:1044560-02-2
Molecular Formula:C₃₁H₃₈N₄O₆
Molecular Weight:562.666
Hs Code.:

Synonyms:17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl ester

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Chemical Property of 17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl ester

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Technology Process of 17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl ester

There total 12 articles about 17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1044559-99-0
1-{[2-(hex-5-enyl-methyl-carbamoyl)-4-(6-methoxy-2-phenylpyrimidin-4-yloxy)cyclopentanecarbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

: 1044560-02-2
17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl ester

Guidance literature:: dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III); In 1,2-dichloro-ethane; Heating / reflux;

Reference yield:

: 259214-54-5,259214-56-7
ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride

: 1044560-02-2
17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

2: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3: triethylsilane; trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

5: dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III) / 1,2-dichloro-ethane / Heating / reflux

With triethylsilane; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III); In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 862174-61-6
3-oxo-2-oxa-bicyclo[2.2.1]heptane-5-carboxylic acid tert-butyl ester

: 1044560-02-2
17-(6-methoxy-2-phenylpyrimidin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hydroxide; water / 1,4-dioxane / 0.75 h / 0 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

3: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

4: triethylsilane; trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

6: dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III) / 1,2-dichloro-ethane / Heating / reflux

With triethylsilane; lithium hydroxide; di-isopropyl azodicarboxylate; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III); In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;