N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Base Information

Chemical Name:N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide
CAS No.:184229-79-6
Molecular Formula:C₅₃H₅₂N₆O₄Si
Molecular Weight:865.119
Hs Code.:

N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Synonyms:N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

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Chemical Property of N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

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Technology Process of N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

There total 7 articles about N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 184229-78-5
N-{9-[(2R,4S,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

: 14470-28-1
mono-4-methoxytrityl chloride

: 184229-79-6
N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: With pyridine; for 1h; Ambient temperature;
DOI:10.1021/ja961788h

Reference yield:

: 64325-78-6
N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

: 184229-79-6
N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / imidazole / CH₂Cl₂ / 12 h / Ambient temperature

2: 77 percent / 80percent aq. AcOH / 0.25 h / Ambient temperature

3: 85 percent / pyridine / 3 h / Ambient temperature

4: 95 percent / NaN₃ / dimethylformamide / 0.25 h / 100 °C

5: 80 percent / H₂ / 5percent Pd/C / ethanol / 8 h / 760 Torr / Ambient temperature

6: 91 percent / pyridine / 1 h / Ambient temperature

With pyridine; 1H-imidazole; sodium azide; hydrogen; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja961788h

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 184229-79-6
N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / imidazole / CH₂Cl₂ / 12 h / Ambient temperature

2: 77 percent / 80percent aq. AcOH / 0.25 h / Ambient temperature

3: 85 percent / pyridine / 3 h / Ambient temperature

4: 95 percent / NaN₃ / dimethylformamide / 0.25 h / 100 °C

5: 80 percent / H₂ / 5percent Pd/C / ethanol / 8 h / 760 Torr / Ambient temperature

6: 91 percent / pyridine / 1 h / Ambient temperature

With pyridine; 1H-imidazole; sodium azide; hydrogen; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja961788h