N-{9-[(2R,4S,5R)-4-Hydroxy-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Base Information

Chemical Name:N-{9-[(2R,4S,5R)-4-Hydroxy-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide
CAS No.:125443-94-9
Molecular Formula:C₃₇H₃₄N₆O₄
Molecular Weight:626.715
Hs Code.:

Synonyms:N-{9-[(2R,4S,5R)-4-Hydroxy-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

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Chemical Property of N-{9-[(2R,4S,5R)-4-Hydroxy-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

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Technology Process of N-{9-[(2R,4S,5R)-4-Hydroxy-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

There total 12 articles about N-{9-[(2R,4S,5R)-4-Hydroxy-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 184229-79-6
N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

: 125443-94-9
N-{9-[(2R,4S,5R)-4-Hydroxy-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 5h; Ambient temperature;
DOI:10.1021/ja961788h

Reference yield:

: 64325-78-6
N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

: 125443-94-9
N-{9-[(2R,4S,5R)-4-Hydroxy-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / imidazole / CH₂Cl₂ / 12 h / Ambient temperature

2: 77 percent / 80percent aq. AcOH / 0.25 h / Ambient temperature

3: 85 percent / pyridine / 3 h / Ambient temperature

4: 95 percent / NaN₃ / dimethylformamide / 0.25 h / 100 °C

5: 80 percent / H₂ / 5percent Pd/C / ethanol / 8 h / 760 Torr / Ambient temperature

6: 91 percent / pyridine / 1 h / Ambient temperature

7: 81 percent / tetrabutylammonium fluoride / tetrahydrofuran / 5 h / Ambient temperature

With pyridine; 1H-imidazole; sodium azide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja961788h

Reference yield:

: 111570-92-4
N⁶-benzoyl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyadenosine

: 125443-94-9
N-{9-[(2R,4S,5R)-4-Hydroxy-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / pyridine / 3 h / Ambient temperature

2: 95 percent / NaN₃ / dimethylformamide / 0.25 h / 100 °C

3: 80 percent / H₂ / 5percent Pd/C / ethanol / 8 h / 760 Torr / Ambient temperature

4: 91 percent / pyridine / 1 h / Ambient temperature

5: 81 percent / tetrabutylammonium fluoride / tetrahydrofuran / 5 h / Ambient temperature

With pyridine; sodium azide; tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja961788h