N-{9-[(2R,4S,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Base Information

Chemical Name:N-{9-[(2R,4S,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide
CAS No.:184229-78-5
Molecular Formula:C₃₃H₃₆N₆O₃Si
Molecular Weight:592.773
Hs Code.:

Synonyms:N-{9-[(2R,4S,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

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Chemical Property of N-{9-[(2R,4S,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

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Technology Process of N-{9-[(2R,4S,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

There total 6 articles about N-{9-[(2R,4S,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 184229-77-4
N-{9-[(2R,4S,5R)-5-Azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

: 184229-78-5
N-{9-[(2R,4S,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 8h; under 760 Torr; Ambient temperature;
DOI:10.1021/ja961788h

Reference yield:

: 64325-78-6
N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

: 184229-78-5
N-{9-[(2R,4S,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / imidazole / CH₂Cl₂ / 12 h / Ambient temperature

2: 77 percent / 80percent aq. AcOH / 0.25 h / Ambient temperature

3: 85 percent / pyridine / 3 h / Ambient temperature

4: 95 percent / NaN₃ / dimethylformamide / 0.25 h / 100 °C

5: 80 percent / H₂ / 5percent Pd/C / ethanol / 8 h / 760 Torr / Ambient temperature

With pyridine; 1H-imidazole; sodium azide; hydrogen; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja961788h

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 184229-78-5
N-{9-[(2R,4S,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / imidazole / CH₂Cl₂ / 12 h / Ambient temperature

2: 77 percent / 80percent aq. AcOH / 0.25 h / Ambient temperature

3: 85 percent / pyridine / 3 h / Ambient temperature

4: 95 percent / NaN₃ / dimethylformamide / 0.25 h / 100 °C

5: 80 percent / H₂ / 5percent Pd/C / ethanol / 8 h / 760 Torr / Ambient temperature

With pyridine; 1H-imidazole; sodium azide; hydrogen; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja961788h