3-(4-methylphenyl)-2-butenoic acid

Base Information

• Chemical Name: 3-(4-methylphenyl)-2-butenoic acid
• CAS No.: 32147-13-0
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.215
• Mol file: 32147-13-0.mol

Synonyms:3-(4-methylphenyl)-2-butenoic acid

Chemical Property of 3-(4-methylphenyl)-2-butenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methylphenyl)-2-butenoic acid

There total 10 articles about 3-(4-methylphenyl)-2-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl (E)-3-p-tolylbut-2-enoate (6305-61-9,115819-11-9,94853-53-9) → 3-(4-methylphenyl)-2-butenoic acid (32147-13-0)

Guidance literature:

With sodium hydroxide; In ethanol; water;

DOI:10.1021/acs.orglett.9b00729

Reference yield: 79.5%

(E)-but-2-enoic acid (107-93-7) + 4-tolyl iodide (624-31-7) → 3-(4-methylphenyl)-2-butenoic acid (32147-13-0)

Guidance literature:

With amberlite IRA-400 (basic); palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

DOI:10.1081/SCC-120015763

Reference yield:

para-methylacetophenone (122-00-9) → 3-(4-methylphenyl)-2-butenoic acid (32147-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: amalgamated zinc; benzene; toluene / anschliessendes Erwaermen mit wss. H₂SO₄ und Erwaermen des Reaktionsprodukts mit Ameisensaeure auf 80grad

2: Hydrolysis

With amalgamated zinc; toluene; benzene;

DOI:10.1039/jr9570000592

upstream raw materials:

ethyl (E)-3-p-tolylbut-2-enoate

chloroacetic acid ethyl ester

para-methylacetophenone

(E)-but-2-enoic acid

Downstream raw materials:

(Z)-3-(p-tolyl)but-2-enoic acid

(E)-1-methyl-4-(1-nitroprop-1-en-2-yl)benzene

(R)-3-(4-methylphenyl)butanoic acid

3-phenyl-3-p-tolylbutanoic acid