2-amino-6-[(2-oxo-2-phenylethyl)sulfanyl]-4-(2-thienyl)-3,5-pyridinedicarbonitrile

Base Information

• Chemical Name: 2-amino-6-[(2-oxo-2-phenylethyl)sulfanyl]-4-(2-thienyl)-3,5-pyridinedicarbonitrile
• CAS No.: 136633-81-3
• Molecular Formula: C₁₉H₁₂N₄OS₂
• Molecular Weight: 376.462
• Mol file: 136633-81-3.mol

Synonyms:2-Amino-6-(2-oxo-2-phenyl-ethylsulfanyl)-4-thiophen-2-yl-pyridine-3,5-dicarbonitrile

Chemical Property of 2-amino-6-[(2-oxo-2-phenylethyl)sulfanyl]-4-(2-thienyl)-3,5-pyridinedicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-6-[(2-oxo-2-phenylethyl)sulfanyl]-4-(2-thienyl)-3,5-pyridinedicarbonitrile

There total 4 articles about 2-amino-6-[(2-oxo-2-phenylethyl)sulfanyl]-4-(2-thienyl)-3,5-pyridinedicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-amino-4-(2-thienyl)-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile (136633-80-2) + α-bromoacetophenone (70-11-1) → 2-Amino-6-(2-oxo-2-phenyl-ethylsulfanyl)-4-thiophen-2-yl-pyridine-3,5-dicarbonitrile (136633-81-3)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 25 ℃; for 0.0833333h;

DOI:10.1007/BF00961252

Reference yield:

2-(2-thienyl)-1-cyanoacrylonitrile (28162-32-5) → 2-Amino-6-(2-oxo-2-phenyl-ethylsulfanyl)-4-thiophen-2-yl-pyridine-3,5-dicarbonitrile (136633-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / 4-methylmorpholine / ethanol / 4 h / 25 °C

2: 4-methylmorpholine / ethanol / Heating

3: 85 percent / 10percent aq. KOH / dimethylformamide / 0.08 h / 25 °C

With 4-methyl-morpholine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1007/BF00961252

Reference yield:

2-cyano-3-(2-thienyl)-2-propenethioamide (68029-46-9) → 2-Amino-6-(2-oxo-2-phenyl-ethylsulfanyl)-4-thiophen-2-yl-pyridine-3,5-dicarbonitrile (136633-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / 4-methylmorpholine / ethanol / 4 h / 25 °C

2: 4-methylmorpholine / ethanol / Heating

3: 85 percent / 10percent aq. KOH / dimethylformamide / 0.08 h / 25 °C

With 4-methyl-morpholine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1007/BF00961252

upstream raw materials:

6-amino-4-(2-thienyl)-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile

α-bromoacetophenone

2-(2-thienyl)-1-cyanoacrylonitrile

2-cyano-3-(2-thienyl)-2-propenethioamide

Downstream raw materials:

3,6-Diamino-2-benzoyl-4-thiophen-2-yl-thieno[2,3-b]pyridine-5-carbonitrile