(S)-(1R,2R)-diethyl [1-hydroxy-2-(p-methoxyphenyl)-2-(p-toluenesulfonamido)ethyl]phosphonate

Base Information

Chemical Name:(S)-(1R*,2R*)-diethyl [1-hydroxy-2-(p-methoxyphenyl)-2-(p-toluenesulfonamido)ethyl]phosphonate
CAS No.:251920-77-1
Molecular Formula:C₂₀H₂₈NO₇PS
Molecular Weight:457.485
Hs Code.:

Synonyms:(S)-(1R*,2R*)-diethyl [1-hydroxy-2-(p-methoxyphenyl)-2-(p-toluenesulfonamido)ethyl]phosphonate

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Chemical Property of (S)-(1R*,2R*)-diethyl [1-hydroxy-2-(p-methoxyphenyl)-2-(p-toluenesulfonamido)ethyl]phosphonate

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Technology Process of (S)-(1R*,2R*)-diethyl [1-hydroxy-2-(p-methoxyphenyl)-2-(p-toluenesulfonamido)ethyl]phosphonate

There total 1 articles about (S)-(1R*,2R*)-diethyl [1-hydroxy-2-(p-methoxyphenyl)-2-(p-toluenesulfonamido)ethyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 127-65-1
chloroamine-T

: 87750-67-2
(E)-diethyl (4-methoxylstyryl)phosphonate

: [(1R,2R)-1-Hydroxy-2-(4-methoxy-phenyl)-2-(toluene-4-sulfonylamino)-ethyl]-phosphonic acid diethyl ester

: 251920-77-1
(S)-(1R*,2R*)-diethyl [1-hydroxy-2-(p-methoxyphenyl)-2-(p-toluenesulfonamido)ethyl]phosphonate

Guidance literature:: With Hydroquinone 1,4-phthalazinediyl diether; potassium dioxotetrahydroxoosmate(VI); In water; acetonitrile; at 20 ℃; for 3h;
DOI:10.1021/jo990060r

Reference yield: 90.0%

: 124-63-0
methanesulfonyl chloride

: 251920-77-1
(S)-(1R*,2R*)-diethyl [1-hydroxy-2-(p-methoxyphenyl)-2-(p-toluenesulfonamido)ethyl]phosphonate

: 251921-05-8
(S)-(1R*,2R*)-diethyl [1-methanesulfonyloxy-2-(p-methoxyphenyl)-2-(p-toluenesulfoamido)ethyl]phosphonate

Guidance literature:: With triethylamine; In dichloromethane; at -10 ℃; for 0.25h;
DOI:10.1021/jo990060r

Reference yield:

: 251920-77-1
(S)-(1R*,2R*)-diethyl [1-hydroxy-2-(p-methoxyphenyl)-2-(p-toluenesulfonamido)ethyl]phosphonate

: (R)-(1R*,2S*)-diethyl [2-(p-methoxyphenyl)-1,2-[N-(p-toluenesulfonyl)aziridino]ethyl]phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 0.25 h / -10 °C

2: 95 percent / K₂CO₃ / dimethylformamide / 2 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Cyclization;
DOI:10.1021/jo990060r