Technology Process of diethyl 2-[11-(4-iodophenoxy)undecyl]malonate
There total 4 articles about diethyl 2-[11-(4-iodophenoxy)undecyl]malonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethyl malonate;
With
sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 0.25h;
Schlenk technique;
Inert atmosphere;
1-(4-iodophenoxy)-11-(4-toluenesulfonyloxy)undecane;
In
tetrahydrofuran; N,N-dimethyl-formamide;
for 9h;
Schlenk technique;
Inert atmosphere;
Reflux;
DOI:10.1246/cl.2011.1450
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / dimethyl sulfoxide / 44 h / 50 °C / Schlenk technique
2.1: triethylamine; dmap / dichloromethane / 45 h / 0 - 20 °C / Schlenk technique
3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
3.2: 9 h / Schlenk technique; Inert atmosphere; Reflux
With
dmap; sodium hydride; potassium carbonate; triethylamine;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1246/cl.2011.1450
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / dimethyl sulfoxide / 44 h / 50 °C / Schlenk technique
2.1: triethylamine; dmap / dichloromethane / 45 h / 0 - 20 °C / Schlenk technique
3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
3.2: 9 h / Schlenk technique; Inert atmosphere; Reflux
With
dmap; sodium hydride; potassium carbonate; triethylamine;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1246/cl.2011.1450
