ethyl 3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl) propanoate

Base Information

Chemical Name:ethyl 3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl) propanoate
CAS No.:1541198-27-9
Molecular Formula:C₁₇H₂₁ClN₂O₃
Molecular Weight:336.818
Hs Code.:

Synonyms:ethyl 3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl) propanoate

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Chemical Property of ethyl 3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl) propanoate

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Technology Process of ethyl 3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl) propanoate

There total 8 articles about ethyl 3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl) propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1071-46-1
hydrogen ethyl malonate

: 1541198-31-5
C₁₃H₁₂ClNO₂

: 1541198-27-9
ethyl 3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl) propanoate

Guidance literature:: With ammonium acetate; In ethanol; for 7h; Heating;

Reference yield:

: 1541198-28-0
C₁₅H₁₇ClO₅

: 1541198-27-9
ethyl 3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl) propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: tert-butyl chloroformate; triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic anhydride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: toluene-4-sulfonic acid / acetone / 14 h / 20 °C / Inert atmosphere

4: ammonium acetate / ethanol / 7 h / Heating

With ammonium acetate; toluene-4-sulfonic acid; tert-butyl chloroformate; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; ethanol; dichloromethane; acetone;

Reference yield:

: 1541198-30-4
C₁₅H₁₆ClNO₃

: 1541198-27-9
ethyl 3-amino-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl) propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / acetone / 14 h / 20 °C / Inert atmosphere

2: ammonium acetate / ethanol / 7 h / Heating

With ammonium acetate; toluene-4-sulfonic acid; In ethanol; acetone;