N-{2-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenyl}-acrylamide

Base Information

Chemical Name:N-{2-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenyl}-acrylamide
CAS No.:1360910-75-3
Molecular Formula:C₂₈H₂₀N₂O₄
Molecular Weight:448.478
Hs Code.:

Synonyms:N-{2-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenyl}-acrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{2-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenyl}-acrylamide

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Technology Process of N-{2-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenyl}-acrylamide

There total 6 articles about N-{2-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenyl}-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.87%

: 1360911-38-1
2-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenylamine

: 79-10-7
acrylic acid

: 1360910-75-3
N-{2-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenyl}-acrylamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dichloromethane; for 12h;

Reference yield:

: 111079-44-8
2-trimethylsilylfuro<3,2-b>pyridine

: 1360910-75-3
N-{2-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenyl}-acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C

2: trichlorophosphate / 2 h / 100 °C / Sealed tube

3: potassium fluoride; N-iodo-succinimide / acetonitrile / 2 h / 20 - 50 °C / Inert atmosphere

4: potassium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 12 h / 85 °C / Sealed tube

5: caesium carbonate / N,N-dimethyl-formamide / 2 h / 150 °C / Microwave irradiation

6: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane / 12 h

With potassium fluoride; N-iodo-succinimide; potassium carbonate; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki Coupling;

Reference yield:

: 1071540-49-2
2-(trimethylsilanyl)furo[3,2-b]pyridine 4-oxide

: 1360910-75-3
N-{2-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenyl}-acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 2 h / 100 °C / Sealed tube

2: potassium fluoride; N-iodo-succinimide / acetonitrile / 2 h / 20 - 50 °C / Inert atmosphere

3: potassium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 12 h / 85 °C / Sealed tube

4: caesium carbonate / N,N-dimethyl-formamide / 2 h / 150 °C / Microwave irradiation

5: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane / 12 h

With potassium fluoride; N-iodo-succinimide; potassium carbonate; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trichlorophosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 3: Suzuki Coupling;