Technology Process of 3-cyclohexyl-3-ethynyl-2-methylene-tetrahydrofuran
There total 7 articles about 3-cyclohexyl-3-ethynyl-2-methylene-tetrahydrofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(triphenylphosphine)gold(I) chloride; silver tetrafluoroborate;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ol102628x
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 - 20 °C / Inert atmosphere
1.3: -78 - 20 °C / Inert atmosphere
2.1: potassium osmate(VI) dihydrate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 24 h / 20 °C
3.1: silica gel-supported sodium periodate / dichloromethane / 2 h / 20 °C / Inert atmosphere
4.1: sodium tetrahydroborate / methanol / 0.25 h / 0 °C / Inert atmosphere
5.1: (triphenylphosphine)gold(I) chloride; silver tetrafluoroborate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
With
potassium osmate(VI) dihydrate; sodium tetrahydroborate; n-butyllithium; (triphenylphosphine)gold(I) chloride; silver tetrafluoroborate; 4-methylmorpholine N-oxide; diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol102628x
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol / 0.25 h / 0 °C / Inert atmosphere
2: (triphenylphosphine)gold(I) chloride; silver tetrafluoroborate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
With
sodium tetrahydroborate; (triphenylphosphine)gold(I) chloride; silver tetrafluoroborate;
In
tetrahydrofuran; methanol;
DOI:10.1021/ol102628x
