4-cyclohexyl-4-ethynyl-hex-5-yne-1,2-diol

Base Information

Chemical Name:4-cyclohexyl-4-ethynyl-hex-5-yne-1,2-diol
CAS No.:1261299-63-1
Molecular Formula:C₁₄H₂₀O₂
Molecular Weight:220.312
Hs Code.:

Synonyms:4-cyclohexyl-4-ethynyl-hex-5-yne-1,2-diol

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Chemical Property of 4-cyclohexyl-4-ethynyl-hex-5-yne-1,2-diol

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Technology Process of 4-cyclohexyl-4-ethynyl-hex-5-yne-1,2-diol

There total 4 articles about 4-cyclohexyl-4-ethynyl-hex-5-yne-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1261299-46-0
(3-ethynyl-hex-5-en-1-yn-3-yl)cyclohexane

: 1261299-63-1
4-cyclohexyl-4-ethynyl-hex-5-yne-1,2-diol

Guidance literature:: With potassium osmate(VI) dihydrate; 4-methylmorpholine N-oxide; In water; tert-butyl alcohol; at 20 ℃; for 24h; chemoselective reaction;
DOI:10.1021/ol102628x

Reference yield:

: 1261299-39-1
3-allyl-3-cyclohexyl-pentane-2,4-dione

: 1261299-63-1
4-cyclohexyl-4-ethynyl-hex-5-yne-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 - 20 °C / Inert atmosphere

1.3: -78 - 20 °C / Inert atmosphere

2.1: potassium osmate(VI) dihydrate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 24 h / 20 °C

With potassium osmate(VI) dihydrate; n-butyllithium; 4-methylmorpholine N-oxide; diisopropylamine; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/ol102628x

Reference yield:

: C₁₁H₁₆O₂

: 1261299-63-1
4-cyclohexyl-4-ethynyl-hex-5-yne-1,2-diol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 10% palladium on activated charcoal; hydrogen

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C / Inert atmosphere

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 3 h / -78 - 20 °C / Inert atmosphere

3.3: -78 - 20 °C / Inert atmosphere

4.1: potassium osmate(VI) dihydrate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 24 h / 20 °C

With potassium osmate(VI) dihydrate; n-butyllithium; 10% palladium on activated charcoal; hydrogen; sodium hydride; 4-methylmorpholine N-oxide; diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;
DOI:10.1021/ol102628x