Technology Process of 3-cyclohexyl-3-ethynyl-pent-4-ynal
There total 5 articles about 3-cyclohexyl-3-ethynyl-pent-4-ynal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
silica gel-supported sodium periodate;
In
dichloromethane;
at 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/ol102628x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 - 20 °C / Inert atmosphere
1.3: -78 - 20 °C / Inert atmosphere
2.1: potassium osmate(VI) dihydrate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 24 h / 20 °C
3.1: silica gel-supported sodium periodate / dichloromethane / 2 h / 20 °C / Inert atmosphere
With
potassium osmate(VI) dihydrate; n-butyllithium; 4-methylmorpholine N-oxide; diisopropylamine;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol102628x
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 10% palladium on activated charcoal; hydrogen
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 2 h / 0 - 20 °C / Inert atmosphere
3.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
3.2: 3 h / -78 - 20 °C / Inert atmosphere
3.3: -78 - 20 °C / Inert atmosphere
4.1: potassium osmate(VI) dihydrate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 24 h / 20 °C
5.1: silica gel-supported sodium periodate / dichloromethane / 2 h / 20 °C / Inert atmosphere
With
potassium osmate(VI) dihydrate; n-butyllithium; 10% palladium on activated charcoal; hydrogen; sodium hydride; 4-methylmorpholine N-oxide; diisopropylamine;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;
DOI:10.1021/ol102628x
