Technology Process of 3-allyl-3-cyclohexyl-pentane-2,4-dione
There total 1 articles about 3-allyl-3-cyclohexyl-pentane-2,4-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-cyclohexyl-pentane-2,4-dione;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
allyl iodid;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/ol102628x
- Guidance literature:
-
3-allyl-3-cyclohexyl-pentane-2,4-dione;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
Inert atmosphere;
With
diethyl chlorophosphate;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 3h;
Inert atmosphere;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ol102628x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 - 20 °C / Inert atmosphere
1.3: -78 - 20 °C / Inert atmosphere
2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.2: 24 h / 0 - 20 °C
3.1: (triphenylphosphine)gold(I) chloride; silver tetrafluoroborate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
With
n-butyllithium; (triphenylphosphine)gold(I) chloride; silver tetrafluoroborate; diisopropylamine; 9-bora-bicyclo[3.3.1]nonane;
In
tetrahydrofuran;
DOI:10.1021/ol102628x
