(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide hydrochloride

Base Information

Chemical Name:(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide hydrochloride
CAS No.:1196505-03-9
Molecular Formula:C₁₉H₁₈BrClFN₅O*ClH
Molecular Weight:503.201
Hs Code.:

Synonyms:(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide hydrochloride

Suppliers and Price of (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide hydrochloride

There total 6 articles about (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1196508-97-0
(R)-tert-butyl 1-(5-bromo-3-(3-chloro-4-fluorobenzamido)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperidin-3-ylcarbamate

: 1196505-03-9
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide hydrochloride

Guidance literature:: (R)-tert-butyl 1-(5-bromo-3-(3-chloro-4-fluorobenzamido)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperidin-3-ylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 1172067-95-6
5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridine

: 1196505-03-9
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid / 0.5 h / 0 °C

2.1: hydrogenchloride; tin(ll) chloride / 0 - 20 °C

2.2: pH 7

3.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 2 h / 20 °C

3.2: 0.17 h

4.1: butan-1-ol / 16 h / 155 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydrogenchloride; nitric acid; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; trifluoroacetic acid; tin(ll) chloride; In dichloromethane; butan-1-ol;

Reference yield:

: 640735-25-7
4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine

: 1196505-03-9
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / -78 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

3.1: nitric acid / 0.5 h / 0 °C

4.1: hydrogenchloride; tin(ll) chloride / 0 - 20 °C

4.2: pH 7

5.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 2 h / 20 °C

5.2: 0.17 h

6.1: butan-1-ol / 16 h / 155 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; sec.-butyllithium; nitric acid; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; trifluoroacetic acid; tin(ll) chloride; In tetrahydrofuran; dichloromethane; cyclohexane; butan-1-ol;