(+)-(1'S,2'S,3S)-3-dibenzylamino-N,4,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide

Base Information

• Chemical Name: (+)-(1'S,2'S,3S)-3-dibenzylamino-N,4,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide
• CAS No.: 678991-40-7
• Molecular Formula: C₃₁H₄₀N₂O₂
• Molecular Weight: 472.671
• Mol file: 678991-40-7.mol

Synonyms:(+)-(1'S,2'S,3S)-3-dibenzylamino-N,4,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide

Chemical Property of (+)-(1'S,2'S,3S)-3-dibenzylamino-N,4,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(1'S,2'S,3S)-3-dibenzylamino-N,4,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide

There total 5 articles about (+)-(1'S,2'S,3S)-3-dibenzylamino-N,4,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-4,4-dimethylpent-2-enamide (678991-35-0) → (+)-(1'S,2'S,3S)-3-dibenzylamino-N,4,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide (678991-40-7)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -105 ℃;

DOI:10.1021/jo051207j

Reference yield: 50.0%

lithium dibenzylamide (85175-35-5) + E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-4,4-dimethylpent-2-enamide (678991-35-0) → (+)-(1'S,2'S,3S)-3-dibenzylamino-N,4,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide (678991-40-7)

Guidance literature:

With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -90 ℃;

DOI:10.1016/j.tet.2007.08.067

Reference yield: 33.0%

dibenzylamine (103-49-1) + E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-4,4-dimethylpent-2-enamide (678991-35-0) → (+)-(1'S,2'S,3S)-3-dibenzylamino-N,4,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide (678991-40-7)

Guidance literature:

With n-butyllithium; In toluene; at -90 ℃; for 22h;

DOI:10.1021/jo0357768

upstream raw materials:

dibenzylamine

E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-4,4-dimethylpent-2-enamide

lithium dibenzylamide

pseudoephedrine

Downstream raw materials:

(+)-(1'S,2'S,3S)-3-(benzyloxycarbonyl)amino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-4,4-dimethylpentanamide

(-)-(3S)-3-((benzyloxycarbonyl)amino)-4,4-dimethylpentanol