N-[8-(3-Benzyloxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-N-methyl-propionamide

Base Information

Chemical Name:N-[8-(3-Benzyloxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-N-methyl-propionamide
CAS No.:344248-63-1
Molecular Formula:C₂₅H₃₁NO₄
Molecular Weight:409.525
Hs Code.:

Synonyms:N-[8-(3-Benzyloxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-N-methyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[8-(3-Benzyloxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-N-methyl-propionamide

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Technology Process of N-[8-(3-Benzyloxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-N-methyl-propionamide

There total 7 articles about N-[8-(3-Benzyloxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-N-methyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-03-8
propionyl chloride

: 65619-88-7
1--4-(methylamino)cyclohexan-1-one ethylene ketal

: 344248-63-1
N-[8-(3-Benzyloxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-N-methyl-propionamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 7h;
DOI:10.1021/jm00135a019

Reference yield:

: 13225-34-8
1-(3-methoxyphenyl)-4-oxocyclohexanecarbonitrile

: 344248-63-1
N-[8-(3-Benzyloxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / BBr₃ / CH₂Cl₂ / 4 h

2: 93 percent / p-toluenesulfonic acid (p-TSA) / benzene / 4 h / Heating

3: 1.) NaH / 1.) DMF, C₆H₆, a) RT, 15 min, b) reflux, 1 h, 2.) DMF, C₆H₆, reflux, 4 h

4: 98 percent / NaOH / ethane-1,2-diol / 18 h / Heating

5: 82 percent / Et₃N, (C₆H₅O)2PON₃ / various solvent(s) / 1 h / 90 °C

6: 71 percent / LiAlH₄ / tetrahydrofuran / 5 h / Heating

7: Et₃N / tetrahydrofuran / 7 h / 0 °C

With sodium hydroxide; lithium aluminium tetrahydride; diphenyl phosphoryl azide; boron tribromide; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; ethylene glycol; benzene;
DOI:10.1021/jm00135a019

Reference yield:

: 65619-83-2
4-cyano-4-(m-hydroxyphenyl)cyclohexanone

: 344248-63-1
N-[8-(3-Benzyloxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / p-toluenesulfonic acid (p-TSA) / benzene / 4 h / Heating

2: 1.) NaH / 1.) DMF, C₆H₆, a) RT, 15 min, b) reflux, 1 h, 2.) DMF, C₆H₆, reflux, 4 h

3: 98 percent / NaOH / ethane-1,2-diol / 18 h / Heating

4: 82 percent / Et₃N, (C₆H₅O)2PON₃ / various solvent(s) / 1 h / 90 °C

5: 71 percent / LiAlH₄ / tetrahydrofuran / 5 h / Heating

6: Et₃N / tetrahydrofuran / 7 h / 0 °C

With sodium hydroxide; lithium aluminium tetrahydride; diphenyl phosphoryl azide; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; ethylene glycol; benzene;
DOI:10.1021/jm00135a019