tert-butyl 2-((5-(cyanomethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetate

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Chemical Name:tert-butyl 2-((5-(cyanomethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetate
CAS No.:1438280-93-3
Molecular Formula:C₂₄H₂₂N₄O₃S
Molecular Weight:446.53
Hs Code.:

Synonyms:tert-butyl 2-((5-(cyanomethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetate

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Chemical Property of tert-butyl 2-((5-(cyanomethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetate

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Technology Process of tert-butyl 2-((5-(cyanomethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetate

There total 6 articles about tert-butyl 2-((5-(cyanomethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1438280-89-7
tert-butyl 2-((4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetate

: 590-17-0
cyanomethyl bromide

: 1438280-93-3
tert-butyl 2-((5-(cyanomethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetate

Guidance literature:: tert-butyl 2-((4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil;

cyanomethyl bromide; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm301694x

Reference yield:

: 1885-29-6
anthranilic acid nitrile

: 1438280-93-3
tert-butyl 2-((5-(cyanomethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / ethanol / 42 h / Reflux

2: potassium tert-butylate / tetrahydrofuran / 2.75 h / 30 °C / Inert atmosphere

3: ethanol / 6 h / Reflux

4: acetyl chloride / ethanol / 12 h / Inert atmosphere; Reflux

5: ISOPROPYLAMIDE; potassium hydroxide / water / 22 - 24 °C

6: sodium hydride / N,N-dimethyl-formamide; mineral oil

With ISOPROPYLAMIDE; potassium tert-butylate; sodium hydride; sodium hydrogencarbonate; acetyl chloride; potassium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm301694x

Reference yield:

: 87223-76-5
(2-cyanophenylamino)acetic acid ethyl ester

: 1438280-93-3
tert-butyl 2-((5-(cyanomethyl)-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / tetrahydrofuran / 2.75 h / 30 °C / Inert atmosphere

2: ethanol / 6 h / Reflux

3: acetyl chloride / ethanol / 12 h / Inert atmosphere; Reflux

4: ISOPROPYLAMIDE; potassium hydroxide / water / 22 - 24 °C

5: sodium hydride / N,N-dimethyl-formamide; mineral oil

With ISOPROPYLAMIDE; potassium tert-butylate; sodium hydride; acetyl chloride; potassium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm301694x