trans-6-[3-(2-chloro-3-methyl-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester

Base Information

Chemical Name:trans-6-[3-(2-chloro-3-methyl-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester
CAS No.:1268239-40-2
Molecular Formula:C₂₆H₃₀ClN₃O₅
Molecular Weight:499.994
Hs Code.:

Synonyms:trans-6-[3-(2-chloro-3-methyl-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester

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Chemical Property of trans-6-[3-(2-chloro-3-methyl-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester

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Technology Process of trans-6-[3-(2-chloro-3-methyl-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester

There total 7 articles about trans-6-[3-(2-chloro-3-methyl-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1268239-88-8
C₂₇H₃₂ClN₃O₅

: 1268239-40-2
trans-6-[3-(2-chloro-3-methyl-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester

Guidance literature:: C₂₇H₃₂ClN₃O₅; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 16h;

With hydrogenchloride; In water;

Reference yield:

: 66405-41-2
(4-oxo-cyclohexyl)-acetic acid methyl ester

: 1268239-40-2
trans-6-[3-(2-chloro-3-methyl-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; methanol / 1 h / 0 °C

2.1: pyridine / dichloromethane / 0 - 20 °C

2.2: 3.5 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 8 h / 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 3 h / Reflux

4.2: 1 h / Reflux

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; diphenyl phosphoryl azide; water; hydrogen; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1268239-40-2
trans-6-[3-(2-chloro-3-methyl-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 19 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 24 h / 20 °C

3.1: hydrogenchloride / water; acetone / 15 h / 20 °C

4.1: sodium tetrahydroborate; methanol / 1 h / 0 °C

5.1: pyridine / dichloromethane / 0 - 20 °C

5.2: 3.5 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 8 h / 20 °C

7.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 3 h / Reflux

7.2: 1 h / Reflux

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

With pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; diphenyl phosphoryl azide; water; hydrogen; sodium hydride; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;