N-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Base Information

Chemical Name:N-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS No.:53112-33-7
Molecular Formula:C10H13N•ClH
Molecular Weight:183.70
Hs Code.:2933499090
Mol file:53112-33-7.mol

Synonyms:N-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride;1,2,3,4-Tetrahydro-2-methylleucoline hydrochloride;2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride;Isoquinoline, 1,2,3,4-tetrahydro-2-methyl-, hydrochloride;1,2,3,4-Tetrahydro-2-methylisoquinoline hydrochloride;SCHEMBL23501375;LS-86008

Suppliers and Price of N-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Methyl-1,2,3,4-tetrahydroisoquinolineHydrochloride
50mg
$ 175.00

TRC
2-Methyl-1,2,3,4-tetrahydroisoquinolineHydrochloride
100mg
$ 245.00

Crysdot
2-Methyl-1,2,3,4-tetrahydroisoquinolinehydrochloride 95+%
5g
$ 1386.00

Crysdot
2-Methyl-1,2,3,4-tetrahydroisoquinolinehydrochloride 95+%
1g
$ 461.00

Chemenu
2-methyl-1,2,3,4-tetrahydroisoquinolinehydrochloride 95%
1g
$ 436.00

Chemenu
2-methyl-1,2,3,4-tetrahydroisoquinolinehydrochloride 95%
5g
$ 1306.00

American Custom Chemicals Corporation
2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 95.00%
5MG
$ 500.28

Alichem
2-Methyl-1,2,3,4-tetrahydroisoquinolinehydrochloride
5g
$ 1543.50

Alichem
2-Methyl-1,2,3,4-tetrahydroisoquinolinehydrochloride
1g
$ 490.00

Alichem
2-Methyl-1,2,3,4-tetrahydroisoquinolinehydrochloride
250mg
$ 205.80

Total 12 raw suppliers

Chemical Property of N-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property:

Melting Point:>150°C (dec.)
Boiling Point:216.7°Cat760mmHg
Flash Point:76.9°C
PSA：3.24000
Density:0.999g/cm³
LogP:2.41440
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly)
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:183.0814771
Heavy Atom Count:12
Complexity:133

Purity/Quality:

98%Min ^*data from raw suppliers

2-Methyl-1,2,3,4-tetrahydroisoquinolineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C[NH+]1CCC2=CC=CC=C2C1.[Cl-]

Technology Process of N-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

There total 4 articles about N-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 67-56-1
methanol

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 53112-33-7
2-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: methanol; 1,2,3,4-tetrahydroisoquinoline; With Ag/TiO₂; at 25 ℃; for 10h; under 760.051 Torr; UV-irradiation;

With hydrogenchloride; In diethyl ether; at 25 ℃; for 12h;
DOI:10.1021/acs.orglett.5b01063

Reference yield:

: C₁₀H₁₁ClN⁽¹⁺⁾*Cl^(1-)

: 53112-33-7
2-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: With hydrogen; tris(2,6-difluorophenyl)borane triethylphosphine oxide; In chloroform; at 70 ℃; for 48h; under 60006 Torr; Autoclave;
DOI:10.1021/jacs.8b12997

Reference yield:

: 1196-38-9
3,4-dihydroisoquinolin-1(2H)-one

: 53112-33-7
2-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C / Sealed tube

1.2: 1 h / 20 - 80 °C / Sealed tube

2.1: tris(2,6-difluorophenyl)borane triethylphosphine oxide; oxalyl dichloride / chloroform / Sealed tube; Inert atmosphere; Glovebox

3.1: hydrogen; tris(2,6-difluorophenyl)borane triethylphosphine oxide / chloroform / 48 h / 70 °C / 60006 Torr / Autoclave

With oxalyl dichloride; hydrogen; sodium hydride; tris(2,6-difluorophenyl)borane triethylphosphine oxide; In chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jacs.8b12997