2-[4-(2-amino-[1,2,4]triazolo[1,5-a]pyrazin-5-yl)-phenyl]-2-methyl-propionitrile

Base Information

Chemical Name:2-[4-(2-amino-[1,2,4]triazolo[1,5-a]pyrazin-5-yl)-phenyl]-2-methyl-propionitrile
CAS No.:1454654-37-5
Molecular Formula:C₁₅H₁₄N₆
Molecular Weight:278.316
Hs Code.:

Synonyms:2-[4-(2-amino-[1,2,4]triazolo[1,5-a]pyrazin-5-yl)-phenyl]-2-methyl-propionitrile

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Chemical Property of 2-[4-(2-amino-[1,2,4]triazolo[1,5-a]pyrazin-5-yl)-phenyl]-2-methyl-propionitrile

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Technology Process of 2-[4-(2-amino-[1,2,4]triazolo[1,5-a]pyrazin-5-yl)-phenyl]-2-methyl-propionitrile

There total 2 articles about 2-[4-(2-amino-[1,2,4]triazolo[1,5-a]pyrazin-5-yl)-phenyl]-2-methyl-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.21%

: 1454654-36-4
2-[4-(6-amino-pyrazin-2-yl)-phenyl]-2-methyl-propionitrile

: 16182-04-0
Ethoxycarbonyl isothiocyanate

: 1454654-37-5
2-[4-(2-amino-[1,2,4]triazolo[1,5-a]pyrazin-5-yl)-phenyl]-2-methyl-propionitrile

Guidance literature:: 2-[4-(6-amino-pyrazin-2-yl)-phenyl]-2-methyl-propionitrile; Ethoxycarbonyl isothiocyanate; In tetrahydrofuran; at 50 ℃; for 12h;

With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; at 80 ℃; for 3h;

Reference yield:

: 850568-67-1
[4-(1-cyano-1-methylethyl)phenyl]boronic acid

: 1454654-37-5
2-[4-(2-amino-[1,2,4]triazolo[1,5-a]pyrazin-5-yl)-phenyl]-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 1 h / 130 °C / Microwave irradiation

2.1: tetrahydrofuran / 12 h / 50 °C

2.2: 3 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; ethanol; toluene;

Reference yield: 25.39%

: 70291-67-7
N-(4-chlorophenyl)morpholine

: 1454654-37-5
2-[4-(2-amino-[1,2,4]triazolo[1,5-a]pyrazin-5-yl)-phenyl]-2-methyl-propionitrile

: 1454654-35-3
2-methyl-2-{4-[2-(4-morpholin-4-yl-phenylamino)-[1,2,4]triazolo[1,5-a]pyrazin-5-yl]-phenyl}-propionitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; DavePhos; In tert-butyl alcohol; at 150 ℃; for 0.5h; Microwave irradiation;