2-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,3-thiazole-5-carbonitrile

Base Information

Chemical Name:2-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,3-thiazole-5-carbonitrile
CAS No.:1213234-92-4
Molecular Formula:C₁₃H₆Cl₃N₅S
Molecular Weight:370.649
Hs Code.:

Synonyms:2-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,3-thiazole-5-carbonitrile

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Chemical Property of 2-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,3-thiazole-5-carbonitrile

Chemical Property:

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Technology Process of 2-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,3-thiazole-5-carbonitrile

There total 8 articles about 2-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,3-thiazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1213234-91-3
2-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,3-thiazole-5-carboxamide

: 1213234-92-4
2-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,3-thiazole-5-carbonitrile

Guidance literature:: With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; at 0 - 20 ℃; for 1.08333h;

Reference yield:

: 7520-67-4
3,4,5-trichloro-benzyl alcohol

: 1213234-92-4
2-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,3-thiazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 3.5 h / 20 °C

2: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tetrahydrofuran / 8 h / 60 °C

3: ammonia / tetrahydrofuran; methanol / 15.08 h / 0 - 60 °C

4: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1.08 h / 0 - 20 °C

With diphenyl phosphoryl azide; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic anhydride; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

: 74878-32-3
4-amino-3,5-dichlorobenzyl alcohol

: 1213234-92-4
2-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,3-thiazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: tert.-butylnitrite; copper dichloride / acetonitrile / 1.58 h / 20 °C

2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 3.5 h / 20 °C

3: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tetrahydrofuran / 8 h / 60 °C

4: ammonia / tetrahydrofuran; methanol / 15.08 h / 0 - 60 °C

5: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1.08 h / 0 - 20 °C

With tert.-butylnitrite; diphenyl phosphoryl azide; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic anhydride; copper dichloride; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; methanol; water; toluene; acetonitrile;