4-(4-carboxy-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:4-(4-carboxy-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester
CAS No.:1204331-78-1
Molecular Formula:C₂₁H₂₀F₃NO₄
Molecular Weight:407.389
Hs Code.:

Synonyms:4-(4-carboxy-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

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Chemical Property of 4-(4-carboxy-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

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Technology Process of 4-(4-carboxy-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

There total 8 articles about 4-(4-carboxy-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1204331-77-0
4-(4-methoxycarbonyl-2-trifluoromethyl-phenyl)piperidine-1-carboxylic acid benzyl ester

: 1204331-78-1
4-(4-carboxy-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: 4-(4-methoxycarbonyl-2-trifluoromethyl-phenyl)piperidine-1-carboxylic acid benzyl ester; With water; potassium carbonate; In methanol; at 20 ℃; for 16h;

With hydrogenchloride; In water;

Reference yield:

: 107317-58-8
4-bromo-3-trifluoromethylbenzoic acid methyl ester

: 1204331-78-1
4-(4-carboxy-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 140 °C

2.1: hydrogen; acetic acid; platinum(IV) oxide / 60 h / Inert atmosphere

3.1: hydrogenchloride / methanol; 1,4-dioxane; dichloromethane / 16 h

4.1: diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

5.1: potassium carbonate / methanol; water / 5 h / 60 °C

5.2: pH 5

With hydrogenchloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; potassium carbonate; acetic acid; diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water; 1.1: |Suzuki Coupling;
DOI:10.1021/jm300601d

Reference yield:

: 161622-14-6
4-bromo-3-(trifluoromethyl)benzoic acid

: 1204331-78-1
4-(4-carboxy-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 80 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 140 °C

3.1: hydrogen; acetic acid; platinum(IV) oxide / 60 h / Inert atmosphere

4.1: hydrogenchloride / methanol; 1,4-dioxane; dichloromethane / 16 h

5.1: diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

6.1: potassium carbonate / methanol; water / 5 h / 60 °C

6.2: pH 5

With hydrogenchloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hydrogen; potassium carbonate; acetic acid; diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water; 2.1: |Suzuki Coupling;
DOI:10.1021/jm300601d