(S)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethanol

Base Information

Chemical Name:(S)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethanol
CAS No.:193416-53-4
Molecular Formula:C₄₆H₆₈O₇Si₂
Molecular Weight:789.213
Hs Code.:

(S)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethanol

Synonyms:(S)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethanol

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Chemical Property of (S)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethanol

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Technology Process of (S)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethanol

There total 13 articles about (S)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 994-30-9
triethylsilyl chloride

: 193416-65-8
(S)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-ethane-1,2-diol

: 193416-53-4
(S)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethanol

Guidance literature:: With 1H-imidazole;
DOI:10.1021/jo9708755

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 193416-53-4
(S)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethanol

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / Et₃N

2: 97 percent / DDQ / CH₂Cl₂

3: 80 percent

4: CrCl₂/NiCl₂ / tetrahydrofuran

5: 1.) PNBA, Ph₃P, DEAD, 2.) K₃CO₃ / 2.) MeOH

6: 96 percent / Et₃N / CH₂Cl₂

7: 94 percent / TBAF

8: 86 percent / Et₃N / acetonitrile / Heating

9: 97 percent / TsOH / methanol

10: 83 percent / imidazole

With 1H-imidazole; chromium dichloride; tetrabutyl ammonium fluoride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo9708755

Reference yield:

: {2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-[2-(4-methoxy-benzyloxy)-ethyl]-3,6-dihydro-2H-pyran-4-yloxy}-triethyl-silane

: 193416-53-4
(S)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethanol

Guidance literature:: Multi-step reaction with 12 steps

1: TBAF, TsOH / tetrahydrofuran

2: 97 percent / K(s-Bu₃BH) / tetrahydrofuran

3: 93 percent / Et₃N

4: 97 percent / DDQ / CH₂Cl₂

5: 80 percent

6: CrCl₂/NiCl₂ / tetrahydrofuran

7: 1.) PNBA, Ph₃P, DEAD, 2.) K₃CO₃ / 2.) MeOH

8: 96 percent / Et₃N / CH₂Cl₂

9: 94 percent / TBAF

10: 86 percent / Et₃N / acetonitrile / Heating

11: 97 percent / TsOH / methanol

12: 83 percent / imidazole

With 1H-imidazole; chromium dichloride; tetrabutyl ammonium fluoride; potassium tri-sec-butyl-borohydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo9708755