5'-[3-bromo-5-(hexyloxymethyl)phenyl]-5-[3-bromo-5-(tetrahydropyran-2-yloxymethyl)phenyl]-2,2'-bipyridine

Base Information

Chemical Name:5'-[3-bromo-5-(hexyloxymethyl)phenyl]-5-[3-bromo-5-(tetrahydropyran-2-yloxymethyl)phenyl]-2,2'-bipyridine
CAS No.:851605-31-7
Molecular Formula:C₃₅H₃₈Br₂N₂O₃
Molecular Weight:694.506
Hs Code.:

Synonyms:5'-[3-bromo-5-(hexyloxymethyl)phenyl]-5-[3-bromo-5-(tetrahydropyran-2-yloxymethyl)phenyl]-2,2'-bipyridine

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Chemical Property of 5'-[3-bromo-5-(hexyloxymethyl)phenyl]-5-[3-bromo-5-(tetrahydropyran-2-yloxymethyl)phenyl]-2,2'-bipyridine

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Technology Process of 5'-[3-bromo-5-(hexyloxymethyl)phenyl]-5-[3-bromo-5-(tetrahydropyran-2-yloxymethyl)phenyl]-2,2'-bipyridine

There total 6 articles about 5'-[3-bromo-5-(hexyloxymethyl)phenyl]-5-[3-bromo-5-(tetrahydropyran-2-yloxymethyl)phenyl]-2,2'-bipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 851605-31-7
5'-[3-bromo-5-(hexyloxymethyl)phenyl]-5-[3-bromo-5-(tetrahydropyran-2-yloxymethyl)phenyl]-2,2'-bipyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: nBuLi / diethyl ether; hexane / 3 h / -78 °C

1.2: 75 percent / 1,2-diiodoethane / diethyl ether; hexane / -78 - 20 °C

2.1: Bu₄NBr; Na₂CO₃; [Pd(PPh₃)4] / toluene; H₂O / 96 h / Heating

3.1: [Pd(PPh₃)4] / toluene / 120 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetrabutylammomium bromide; sodium carbonate; In diethyl ether; hexane; water; toluene;
DOI:10.1002/ejoc.200400744

Reference yield:

: 73290-22-9
2-bromo-5-iodo-pyridine

: 851605-31-7
5'-[3-bromo-5-(hexyloxymethyl)phenyl]-5-[3-bromo-5-(tetrahydropyran-2-yloxymethyl)phenyl]-2,2'-bipyridine

Guidance literature:: Multi-step reaction with 2 steps

1: Bu₄NBr; Na₂CO₃; [Pd(PPh₃)4] / toluene; H₂O / 96 h / Heating

2: [Pd(PPh₃)4] / toluene / 120 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium carbonate; In water; toluene;
DOI:10.1002/ejoc.200400744

Reference yield:

: 225932-10-5
2-(3,5-dibromobenzyloxy)tetrahydro-2H-pyran

: 851605-31-7
5'-[3-bromo-5-(hexyloxymethyl)phenyl]-5-[3-bromo-5-(tetrahydropyran-2-yloxymethyl)phenyl]-2,2'-bipyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / diethyl ether; hexane / 72 h / -78 °C

1.2: triisopropyl borate / diethyl ether; hexane / -78 - 20 °C

1.3: 83 percent / toluene / 48 h / Heating

2.1: Bu₄NBr; Na₂CO₃; [Pd(PPh₃)4] / toluene; H₂O / 96 h / Heating

3.1: [Pd(PPh₃)4] / toluene / 120 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetrabutylammomium bromide; sodium carbonate; In diethyl ether; hexane; water; toluene;
DOI:10.1002/ejoc.200400744