CID 6971145

Base Information

Chemical Name:CID 6971145
CAS No.:52809-07-1
Molecular Formula:C5H7N3O5
Molecular Weight:189.128
Hs Code.:2934999090
Mol file:52809-07-1.mol

Synonyms:2jbk;2or4;3fee

Suppliers and Price of CID 6971145

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
L-Quisqualic acid
1mg
$ 333.00

TRC
(+)-QuisqualicAcid
50mg
$ 730.00

Tocris
L-Quisqualicacid ≥99%(HPLC)
50
$ 908.00

Tocris
L-Quisqualicacid ≥99%(HPLC)
1
$ 103.00

Tocris
L-Quisqualicacid ≥99%(HPLC)
10
$ 216.00

Sigma-Aldrich
Quisqualic acid powder
5mg
$ 295.00

Sigma-Aldrich
Quisqualic acid powder
1mg
$ 86.40

Sigma-Aldrich
Quisqualic acid powder
10mg
$ 410.00

Sigma-Aldrich
Quisqualic acid powder
25mg
$ 1050.00

Medical Isotopes, Inc.
(+)-QuisqualicAcid
5 mg
$ 690.00

Total 43 raw suppliers

Chemical Property of CID 6971145

Chemical Property:

Appearance/Colour:off-white solid
Melting Point:185-187 °C
Refractive Index:1.571
Boiling Point:324.36°C (rough estimate)
PKA:2.12±0.10(Predicted)
PSA：131.32000
Density:1.679 g/cm³
LogP:-1.75820
Storage Temp.:2-8°C
Solubility.:NH4OH 1 M: 20 mg/mL, clear, colorless
Water Solubility.:Soluble in ethanol, water. Insoluble in organic solvents.
XLogP3:-3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:189.03857033
Heavy Atom Count:13
Complexity:259

Purity/Quality:

≥97% ^*data from raw suppliers

L-Quisqualic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 20/21/22
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(C(C(=O)[O-])[NH3+])N1C(=O)NC(=O)O1
Isomeric SMILES:C([C@@H](C(=O)[O-])[NH3+])N1C(=O)NC(=O)O1
Description L-Quisqualic acid is a natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC50s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as the ionotropic kainate receptor (GRIK4; Ki = 6.43 nM). L-Quisqualic acid is used to study receptor dynamics and as an excitotoxin to selectively destroy neurons in the brain or spinal cord.
Uses An amino acid that is able to function as an agonist at multiple excitatory amino acid receptor substrates in the central nervous system. It also has high affinity for the kainate, AMPA and the metabotropic receptors. Inhibits the Ca2+/Cl-dependent glutamic acid uptake system in brain synaptic plasma membrane preparations. Quisqualic acid has been used to test ligand-gated receptors in spiral ganglion neurons. Quisqualic acid is used to differentiate between mGluR-1 and mGluR-4. L-Quisqualic acid is an activator of GluR.

Technology Process of CID 6971145

There total 7 articles about CID 6971145 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 5147-00-2,25248-96-8,44901-25-9
O-acetyl-L-serine

: 24603-68-7
[1,2,4]oxadiazolidine-3,5-dione

: 52809-07-1
quisqualic acid

Guidance literature:: With gallium(III) nitrate; pyridoxal 5'-phosphate; In water; at 62 - 65 ℃; for 2h; pH=5.0;

Reference yield:

: (S)-2-tert-Butoxycarbonylamino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid tert-butyl ester

: 52809-07-1
quisqualic acid

Guidance literature:: With Amberlite IR-45; methoxybenzene; trifluoroacetic acid; In N,N-dimethyl-formamide; at 0 ℃; for 16h; Yield given;
DOI:10.1016/0040-4039(96)01061-1

Reference yield:

: 52-90-4
L-Cysteine

: 24603-68-7
[1,2,4]oxadiazolidine-3,5-dione

: 52809-07-1
quisqualic acid

Guidance literature:: With Tris-HCl buffer; at 30 ℃; for 0.166667h; β-cyano-L-alanine synthase (from Spinacia oleracea, Chenopodiaceae);
DOI:10.1016/0031-9422(88)80087-6