3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazine

Base Information

Chemical Name:3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazine
CAS No.:1161076-47-6
Molecular Formula:C₁₆H₁₃ClFN₅
Molecular Weight:329.764
Hs Code.:

Synonyms:3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazine

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Chemical Property of 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazine

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Technology Process of 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazine

There total 4 articles about 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1161076-46-5
phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

: 1161076-47-6
3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1h; under 750.075 Torr; Inert atmosphere;

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 1161076-47-6
3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 18 h / 20 °C / Inert atmosphere

2: 1,3,5-trimethyl-benzene / 18 h / 165 °C

3: 1,3,5-trimethyl-benzene / 4 h / 140 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C / 750.08 Torr / Inert atmosphere

With hydrogen; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In methanol; 1,3,5-trimethyl-benzene;

Reference yield:

: 474511-91-6
4-[(4-fluorophenyl)ethynyl]-2-(methylthio)pyrimidine

: 1161076-47-6
3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: 1,3,5-trimethyl-benzene / 18 h / 165 °C

2: 1,3,5-trimethyl-benzene / 4 h / 140 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C / 750.08 Torr / Inert atmosphere

With hydrogen; palladium 10% on activated carbon; In methanol; 1,3,5-trimethyl-benzene;