2-(8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

Base Information

Chemical Name:2-(8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile
CAS No.:1255701-29-1
Molecular Formula:C₁₆H₁₄ClN₃O
Molecular Weight:299.76
Hs Code.:

Synonyms:2-(8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

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Chemical Property of 2-(8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

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Technology Process of 2-(8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

There total 2 articles about 2-(8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1255701-30-4
8-chloro-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine

: 590-17-0
cyanomethyl bromide

: 1255701-29-1
2-(8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 16h; Product distribution / selectivity;

Reference yield:

: 7568-93-6,1936-63-6
2-Amino-1-phenylethanol

: 1255701-29-1
2-(8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 2 h / 20 °C

1.2: 0.5 h

2.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 16 h / 20 °C

With sodium hydride; triethylamine; In tetrahydrofuran; methanol;

Reference yield:

: 958245-18-6
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

: 1255701-29-1
2-(8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

: 1255700-37-8
(R)-2-(8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

Guidance literature:: With caesium carbonate; palladium diacetate; In 1,2-dimethoxyethane; at 100 ℃; for 4h; Inert atmosphere; Sealed microwave vial;