methyl-2-(4-(4-chlorophenylsulfonyl)-5,8-difluorochroman-3-yl)-5-hydroxypentanoate

Base Information

Chemical Name:methyl-2-(4-(4-chlorophenylsulfonyl)-5,8-difluorochroman-3-yl)-5-hydroxypentanoate
CAS No.:944951-67-1
Molecular Formula:C₂₁H₂₁ClF₂O₆S
Molecular Weight:474.91
Hs Code.:

Synonyms:methyl-2-(4-(4-chlorophenylsulfonyl)-5,8-difluorochroman-3-yl)-5-hydroxypentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl-2-(4-(4-chlorophenylsulfonyl)-5,8-difluorochroman-3-yl)-5-hydroxypentanoate

Chemical Property:

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Technology Process of methyl-2-(4-(4-chlorophenylsulfonyl)-5,8-difluorochroman-3-yl)-5-hydroxypentanoate

There total 1 articles about methyl-2-(4-(4-chlorophenylsulfonyl)-5,8-difluorochroman-3-yl)-5-hydroxypentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1100361-96-3
C₂₀H₁₇ClF₂O₅S

: 944951-67-1
methyl-2-(4-(4-chlorophenylsulfonyl)-5,8-difluorochroman-3-yl)-5-hydroxypentanoate

Guidance literature:: With magnesium ethoxide;

Reference yield:

: 944951-67-1
methyl-2-(4-(4-chlorophenylsulfonyl)-5,8-difluorochroman-3-yl)-5-hydroxypentanoate

: 124-63-0
methanesulfonyl chloride

: 1100362-57-9
C₂₂H₂₃ClF₂O₈S₂

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 944951-67-1
methyl-2-(4-(4-chlorophenylsulfonyl)-5,8-difluorochroman-3-yl)-5-hydroxypentanoate

: (10a-(4-chlorophenylsulfonyl)-1,4-difluoro-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-7-yl)methanamine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: potassium tert-butylate / tetrahydrofuran / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran / 20 °C

4: triethylamine

5: sodium azide

6: triphenylphosphine / water

With sodium tetrahydroborate; sodium azide; potassium tert-butylate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1007/s11426-011-4388-6