tert-butyl 2-((2-bromo-5-fluorophenyl)(hydroxy)methyl)acrylate

Base Information

• Chemical Name: tert-butyl 2-((2-bromo-5-fluorophenyl)(hydroxy)methyl)acrylate
• CAS No.: 1431328-93-6
• Molecular Formula: C₁₄H₁₆BrFO₃
• Molecular Weight: 331.182
• Mol file: 1431328-93-6.mol

Synonyms:tert-butyl 2-((2-bromo-5-fluorophenyl)(hydroxy)methyl)acrylate

Chemical Property of tert-butyl 2-((2-bromo-5-fluorophenyl)(hydroxy)methyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-((2-bromo-5-fluorophenyl)(hydroxy)methyl)acrylate

There total 1 articles about tert-butyl 2-((2-bromo-5-fluorophenyl)(hydroxy)methyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + 2-bromo-5-fluorobenzaldehyde (94569-84-3) → tert-butyl 2-((2-bromo-5-fluorophenyl)(hydroxy)methyl)acrylate (1431328-93-6)

Guidance literature:

With 3-quinuclidinol; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2017.06.024

Reference yield: 94.0%

tert-butyl 2-((2-bromo-5-fluorophenyl)(hydroxy)methyl)acrylate (1431328-93-6) + acetic anhydride (108-24-7) → tert-butyl 2-(acetoxy(2-bromo-5-fluorophenyl)methyl)acrylate (1431328-94-7)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

tert-butyl 2-((2-bromo-5-fluorophenyl)(hydroxy)methyl)acrylate (1431328-93-6) → 10-methyl 6-(2-methyl-2-propanyl) 13-cyclohexyl-3-fluoro-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylate (1431328-96-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 2 h / 20 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.08 h / 20 °C

2.2: 3 h / -47 - -20 °C

3.1: palladium diacetate; tricyclohexylphosphine tetrafluoroborate; potassium acetate / N,N-dimethyl acetamide / 6 h / 122 °C / Inert atmosphere

With dmap; potassium tert-butylate; potassium acetate; palladium diacetate; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine tetrafluoroborate; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

upstream raw materials:

tert-Butyl acrylate

2-bromo-5-fluorobenzaldehyde

Downstream raw materials:

tert-butyl 2-(acetoxy(2-bromo-5-fluorophenyl)methyl)acrylate

10-methyl 6-(2-methyl-2-propanyl) 13-cyclohexyl-3-fluoro-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylate

5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

(1aS,12bR)-8-cyclohexyl-11-fluoro-5-(methoxycarbonyl)-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid