N₁-(2-(2-hydroxyethoxy)ethyl)-N₃-(4-(piperidin-1-yl)-2-((5-(3-(trifluoromethyl)phenyl)pyrazin-2-yl)carbamoyl)phenyl)isophthalamide

Base Information

• Chemical Name: N₁-(2-(2-hydroxyethoxy)ethyl)-N₃-(4-(piperidin-1-yl)-2-((5-(3-(trifluoromethyl)phenyl)pyrazin-2-yl)carbamoyl)phenyl)isophthalamide
• CAS No.: 1354652-60-0
• Molecular Formula: C₃₅H₃₅F₃N₆O₅
• Molecular Weight: 676.695
• Mol file: 1354652-60-0.mol

Synonyms:N₁-(2-(2-hydroxyethoxy)ethyl)-N₃-(4-(piperidin-1-yl)-2-((5-(3-(trifluoromethyl)phenyl)pyrazin-2-yl)carbamoyl)phenyl)isophthalamide

Chemical Property of N₁-(2-(2-hydroxyethoxy)ethyl)-N₃-(4-(piperidin-1-yl)-2-((5-(3-(trifluoromethyl)phenyl)pyrazin-2-yl)carbamoyl)phenyl)isophthalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(2-(2-hydroxyethoxy)ethyl)-N₃-(4-(piperidin-1-yl)-2-((5-(3-(trifluoromethyl)phenyl)pyrazin-2-yl)carbamoyl)phenyl)isophthalamide

There total 7 articles about N₁-(2-(2-hydroxyethoxy)ethyl)-N₃-(4-(piperidin-1-yl)-2-((5-(3-(trifluoromethyl)phenyl)pyrazin-2-yl)carbamoyl)phenyl)isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

3-((2-(2-hydroxyethoxy)ethyl)carbamoyl)benzoic acid (1354652-87-1) + 2-amino-5-(piperidine-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide (1354652-90-6) → N1-(2-(2-hydroxyethoxy)ethyl)-N3-(4-(piperidin-1-yl)-2-((5-(3-(trifluoromethyl)phenyl)pyrazin-2-yl)carbamoyl)phenyl)isophthalamide (1354652-60-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 40 ℃;

Reference yield:

(meta-(trifluoromethyl)phenyl)boronic acid (1423-26-3) → N1-(2-(2-hydroxyethoxy)ethyl)-N3-(4-(piperidin-1-yl)-2-((5-(3-(trifluoromethyl)phenyl)pyrazin-2-yl)carbamoyl)phenyl)isophthalamide (1354652-60-0)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water; methanol / 135 °C / Inert atmosphere; Sealed tube

2: pyridine / dichloromethane / 2 h / 25 °C

3: potassium carbonate / N,N-dimethyl-formamide / 100 °C

4: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 40 °C

With pyridine; hydrogen; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide (1354652-88-2) → N1-(2-(2-hydroxyethoxy)ethyl)-N3-(4-(piperidin-1-yl)-2-((5-(3-(trifluoromethyl)phenyl)pyrazin-2-yl)carbamoyl)phenyl)isophthalamide (1354652-60-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

2: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 40 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

benzene 1,3-dicarboxylic acid monomethyl ester

(meta-(trifluoromethyl)phenyl)boronic acid

methyl 3-((2-(2-hydroxyethoxy)ethyl)carbamoyl)benzoate

3-((2-(2-hydroxyethoxy)ethyl)carbamoyl)benzoic acid