Potassium; (R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-3-phenyl-propionate

Base Information

• Chemical Name: Potassium; (R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-3-phenyl-propionate
• CAS No.: 132574-61-9
• Molecular Formula: C₁₄H₁₆NO₄*K
• Molecular Weight: 301.384

Synonyms:Potassium; (R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-3-phenyl-propionate

Chemical Property of Potassium; (R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-3-phenyl-propionate

Chemical Property:

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Technology Process of Potassium; (R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-3-phenyl-propionate

There total 1 articles about Potassium; (R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-3-phenyl-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

D-(R)-phenylalanine (673-06-3,25191-15-5,658-69-5,67675-33-6) + acetoacetic acid methyl ester (105-45-3) → Potassium; (R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-3-phenyl-propionate (132574-61-9)

Guidance literature:

With potassium hydroxide; In methanol; for 3h; Ambient temperature;

DOI:10.1246/cl.1991.21

Reference yield:

Potassium; (R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-3-phenyl-propionate (132574-61-9) → (R)-2-Amino-3-phenyl-propionic acid 2-((R)-2-amino-3-phenyl-propionyloxy)-ethyl ester; compound with toluene-4-sulfonic acid (69454-08-6,132357-32-5,132357-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 5 h / 50 °C

2: p-TsOH*H₂O / acetone / 0.5 h

With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; acetone;

DOI:10.1246/cl.1991.21

Reference yield:

Potassium; (R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-3-phenyl-propionate (132574-61-9) + ethylene dibromide (106-93-4) → (E)-3-((R)-1-{2-[(R)-2-((E)-2-Methoxycarbonyl-1-methyl-vinylamino)-3-phenyl-propionyloxy]-ethoxycarbonyl}-2-phenyl-ethylamino)-but-2-enoic acid methyl ester (132574-67-5)

Guidance literature:

In N,N-dimethyl-formamide; at 50 ℃; for 5h;

DOI:10.1246/cl.1991.21

upstream raw materials:

D-(R)-phenylalanine

acetoacetic acid methyl ester

Downstream raw materials:

(E)-3-((R)-1-{2-[(R)-2-((E)-2-Methoxycarbonyl-1-methyl-vinylamino)-3-phenyl-propionyloxy]-ethoxycarbonyl}-2-phenyl-ethylamino)-but-2-enoic acid methyl ester

(R)-2-Amino-3-phenyl-propionic acid 2-((R)-2-amino-3-phenyl-propionyloxy)-ethyl ester; compound with toluene-4-sulfonic acid

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