N-(4-bromo-2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

Base Information

• Chemical Name: N-(4-bromo-2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide
• CAS No.: 1439384-18-5
• Molecular Formula: C₁₇H₁₄BrNO₃S
• Molecular Weight: 392.273
• Mol file: 1439384-18-5.mol

Synonyms:N-(4-bromo-2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

Chemical Property of N-(4-bromo-2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-bromo-2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

There total 5 articles about N-(4-bromo-2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-(4-bromo-2-formylphenyl)-4-methylbenzenesulfonamide (34159-05-2) + propargyl bromide (106-96-7) → N-(4-bromo-2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide (1439384-18-5)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01295

Reference yield:

5-bromo-2-nitrobenzylic alcohol (1241894-37-0) → N-(4-bromo-2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide (1439384-18-5)

Guidance literature:

Multi-step reaction with 4 steps

1: iron; ammonium chloride / methanol; water / 8 h / 80 °C / Inert atmosphere

2: pyridine / dichloromethane / 3 h / 25 °C / Inert atmosphere

3: pyridinium chlorochromate / dichloromethane / 1.5 h / 25 °C / Inert atmosphere

4: potassium carbonate / acetonitrile / 6 h / 80 °C / Inert atmosphere

With pyridine; iron; potassium carbonate; ammonium chloride; pyridinium chlorochromate; In methanol; dichloromethane; water; acetonitrile;

DOI:10.1021/acs.orglett.9b01295

Reference yield:

(2-amino-5-bromophenyl)methanol (20712-12-3) → N-(4-bromo-2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide (1439384-18-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 3 h / 25 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 1.5 h / 25 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 6 h / 80 °C / Inert atmosphere

With pyridine; potassium carbonate; pyridinium chlorochromate; In dichloromethane; acetonitrile;

DOI:10.1021/acs.orglett.9b01295

upstream raw materials:

N-(4-bromo-2-formylphenyl)-4-methylbenzenesulfonamide

propargyl bromide

(2-amino-5-bromophenyl)methanol

5-bromo-2-nitrobenzylic alcohol

Downstream raw materials:

7-bromo-1-tosyl-1H-benzo[b]azepin-3(2H)-one