34159-05-2

Basic information

• Product Name: N-(4-Bromo-2-formylphenyl)-4-methylbenzenesulfonamide
• Synonyms: N-(4-Bromo-2-formylphenyl)-4-methylbenzenesulfonamide
• CAS NO: 34159-05-2
• Molecular Formula: C₁₄H₁₂BrNO₃S
• Molecular Weight: 354.21898
• Mol File: 34159-05-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 479.4°Cat760mmHg
• Flash Point: 243.7°C
• Appearance: /
• Density: 1.59g/cm³
• Vapor Pressure: 2.37E-09mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: N-(4-Bromo-2-formylphenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Bromo-2-formylphenyl)-4-methylbenzenesulfonamide(34159-05-2)
• EPA Substance Registry System: N-(4-Bromo-2-formylphenyl)-4-methylbenzenesulfonamide(34159-05-2)

Safety Data

• Hazardous Substances Data: 34159-05-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H12BrNO3S/c1-10-2-5-13(6-3-10)20(18,19)16-14-7-4-12(15)8-11(14)9-17/h2-9,16H,1H3

Upstream product

• 329281-02-9 N-(4-bromo-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 31100-21-7 5-bromo-2-[(4-methylphenyl)sulfonamido]benzoic acid 
• 20357-20-4 5-bromo-2-nitrobenzaldehyde 
• 1241894-37-0 5-bromo-2-nitrobenzylic alcohol 
• 98-59-9 p-toluenesulfonyl chloride 
• 20712-12-3 (2-amino-5-bromophenyl)methanol 
• 941-55-9 4-toluenesulfonyl azide 
• 52727-57-8 5-bromo-2-aminobenzoic acid methyl ester 
• 90312-02-0 N-(2-hydroxymethylphenyl)-4-methylbenzenesulfonamide 
• 5344-90-1 2-Aminobenzyl alcohol 
• 70-55-3 toluene-4-sulfonamide 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 223526-84-9 methyl 5-bromo-2-{[(4-methylphenyl)sulfonyl]amino}benzoate 

Downstream Products

• 943819-82-7 ethyl 4-{(4-bromo-2-formylphenyl)[(4-methylphenyl)sulfonyl]amino}butanoate 
• 1242061-56-8 C₂₈H₂₉BrN₂O₂S 
• 1242061-58-0 C₂₇H₃₇BrN₂O₄SSi 
• 1242061-54-6 C₂₆H₂₅BrN₂O₃S 
• 1242061-57-9 C₂₂H₂₅BrN₂O₄S 
• 1448809-05-9 5-bromo-2-(iodomethylene)-1-tosylindolin-3-one 
• 1448808-96-5 1-(5-bromo-2-(tosylamino)phenyl)prop-2-yn-1-ol 
• 1613505-51-3 C₂₄H₁₈BrNO₃S 
• 1613505-73-9 C₁₇H₁₆BrNO₃S 

Relevant articles and documents

Copper-Catalyzed (4+1) Cascade Annulation of Terminal Alkynes with 2-(Tosylmethyl)anilines: Synthesis of 2,3-Disubstituted Indoles

A novel strategy based on Cu-catalyzed (4+1) cascade annulation of terminal alkynes as one-carbon synthons with 2-(tosylmethyl)anilines has been developed for the expeditious synthesis of 2,3-disubstituted indoles, in which in situ generations of aza-o-quinone methides and alkynyl-copper(I) species are involved. This annulation provides an effective method for the assembly of synthetically and structurally interesting 2,3-disubstituted indoles.

Palladium-Catalyzed Regioselective Syn-Chloropalladation-Olefin Insertion-Oxidative Chlorination Cascade: Synthesis of Dichlorinated Tetrahydroquinolines

A palladium catalyzed cascade process involving syn-chloropalladation, intramolecular olefin insertion, and oxidative C-Cl bond formation reactions was demonstrated for the synthesis of dichlorinated tetrahydroquinolines in high yields (up to 93%). The N-propargyl arylamines having a tethered α,β-unsaturated carbonyl moiety underwent a regioselective syn-chloropalladation followed by a Heck-type reaction to deliver the tetrahydroquinoline scaffold. The rare insertion of the second chlorine atom was rationalized comprising a PdII/IV catalytic cycle and oxidative cleavage of the C-PdII bond.

Benzoazepine-Fused Isoindolines via Intramolecular (3 + 2)-Cycloadditions of Azomethine Ylides with Dinitroarenes

Aminobenzaldehydes bearing a pendant 3,5-dinitrophenyl group react thermally with N-substituted α-amino acids to form unprecedented benzoazepine-fused isoindolines. The reaction proceeds via a dearomatization/rearomatization sequence involving an intramolecular (3 + 2)-cycloaddition between the in situ formed azomethine ylide and the dinitroarene. Various glycine derivatives are tolerated as well as branched substrates based on cyclic, α-mono-, and α,α-disubstituted amino acids, giving single diastereomers in many cases. The method is scalable and gives products with a nitro group ready for further manipulation.