N-(4-((2-(azidomethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-(4-((2-(azidomethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
CAS No.:1374006-84-4
Molecular Formula:C₁₈H₂₀F₃N₇O₃S
Molecular Weight:471.463
Hs Code.:

Synonyms:N-(4-((2-(azidomethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Chemical Property of N-(4-((2-(azidomethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Technology Process of N-(4-((2-(azidomethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

There total 7 articles about N-(4-((2-(azidomethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129768-24-7
1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

: 1374006-99-1
C₁₉H₂₂N₂O₇S₂

: 1374006-84-4
N-(4-((2-(azidomethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: C₁₉H₂₂N₂O₇S₂; With palladium on activated charcoal; hydrogen; In methanol;

1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane;

With sodium azide; In dimethyl sulfoxide;

Reference yield:

: 349098-93-7
C₁₂H₁₆N₂O₅S

: 1374006-84-4
N-(4-((2-(azidomethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane

2: tin(II) chloride dihdyrate / methanol; dichloromethane

3: sodium azide / N,N-dimethyl-formamide / 5 h / 120 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane

With sodium azide; tin(II) chloride dihdyrate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201699w

Reference yield:

: 3433-37-2
piperidin-2-ylmethanol

: 1374006-84-4
N-(4-((2-(azidomethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / acetone / 10 h / 20 °C

2: dichloromethane

3: tin(II) chloride dihdyrate / methanol; dichloromethane

4: sodium azide / N,N-dimethyl-formamide / 5 h / 120 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane

With sodium azide; tin(II) chloride dihdyrate; sodium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm201699w