methyl (2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)(methoxy)carbamate

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Chemical Name:methyl (2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)(methoxy)carbamate
CAS No.:1439684-11-3
Molecular Formula:C₂₂H₁₉F₅N₄O₄
Molecular Weight:498.409
Hs Code.:

Synonyms:methyl (2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)(methoxy)carbamate

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Chemical Property of methyl (2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)(methoxy)carbamate

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Technology Process of methyl (2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)(methoxy)carbamate

There total 2 articles about methyl (2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)(methoxy)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1257599-53-3
C₁₂H₈F₅N₃O

: C₁₁H₁₄BrNO₃

: 1439684-11-3
methyl (2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)(methoxy)carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;
DOI:10.1016/j.bmcl.2013.04.045

Reference yield:

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 1439684-11-3
methyl (2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)(methoxy)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; hydrogenchloride / water

2: toluene / Reflux; Dean-Stark

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

With hydrogenchloride; sodium carbonate; potassium carbonate; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2013.04.045