1-(2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-1-methoxy-3-methylurea

Base Information

Chemical Name:1-(2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-1-methoxy-3-methylurea
CAS No.:1439684-43-1
Molecular Formula:C₂₂H₂₀F₅N₅O₃
Molecular Weight:497.425
Hs Code.:

Synonyms:1-(2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-1-methoxy-3-methylurea

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Chemical Property of 1-(2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-1-methoxy-3-methylurea

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Technology Process of 1-(2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-1-methoxy-3-methylurea

There total 3 articles about 1-(2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-1-methoxy-3-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1439684-11-3
methyl (2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)(methoxy)carbamate

: 74-89-5
methylamine

: 1439684-43-1
1-(2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-1-methoxy-3-methylurea

Guidance literature:: In methanol; water; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.04.045

Reference yield:

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 1439684-43-1
1-(2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-1-methoxy-3-methylurea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; hydrogenchloride / water

2: toluene / Reflux; Dean-Stark

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

4: water; methanol / 1 h / 20 °C

With hydrogenchloride; sodium carbonate; potassium carbonate; In methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2013.04.045

Reference yield:

: 1257599-53-3
C₁₂H₈F₅N₃O

: 1439684-43-1
1-(2-(((2-((2,4-difluorophenyl)amino)-5-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-1-methoxy-3-methylurea

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

2: water; methanol / 1 h / 20 °C

With potassium carbonate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.04.045