(S)-2-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-hexanoylamino]-3-phenyl-propionic acid methyl ester

Base Information

• Chemical Name: (S)-2-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-hexanoylamino]-3-phenyl-propionic acid methyl ester
• CAS No.: 786709-50-0
• Molecular Formula: C₃₄H₄₈N₄O₈
• Molecular Weight: 640.777

Synonyms:(S)-2-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-hexanoylamino]-3-phenyl-propionic acid methyl ester

Chemical Property of (S)-2-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-hexanoylamino]-3-phenyl-propionic acid methyl ester

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Technology Process of (S)-2-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-hexanoylamino]-3-phenyl-propionic acid methyl ester

There total 4 articles about (S)-2-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-hexanoylamino]-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Val-ONSu (3392-12-9) + Lys(N-Cbz)-Phe-OMe (58328-63-5) → (S)-2-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-hexanoylamino]-3-phenyl-propionic acid methyl ester (786709-50-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/ol048845t

Reference yield:

Boc-Lys(Z)-OSu (34404-36-9) → (S)-2-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-hexanoylamino]-3-phenyl-propionic acid methyl ester (786709-50-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 20 °C

2: aq. HCl / dioxane; CH₂Cl₂ / 2 h

3: 259 mg / Et₃N / CH₂Cl₂ / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ol048845t

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → (S)-2-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-hexanoylamino]-3-phenyl-propionic acid methyl ester (786709-50-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 20 °C

2: aq. HCl / dioxane; CH₂Cl₂ / 2 h

3: 259 mg / Et₃N / CH₂Cl₂ / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ol048845t

upstream raw materials:

Boc-Val-ONSu

Lys(N-Cbz)-Phe-OMe

Boc-Lys(Z)-OSu

methyl (2S)-2-amino-3-phenylpropanoate

Downstream raw materials:

Boc-V-(δ-Boc)K-F

2-[6-tert-butoxycarbonylamino-2-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-hexanoylamino]-3-phenyl-propionic acid methyl ester

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