3-bromo-4-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester

Base Information

Chemical Name:3-bromo-4-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester
CAS No.:866624-77-3
Molecular Formula:C₂₃H₂₃BrN₂O₂
Molecular Weight:439.352
Hs Code.:

Synonyms:3-bromo-4-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester

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Chemical Property of 3-bromo-4-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester

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Technology Process of 3-bromo-4-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester

There total 2 articles about 3-bromo-4-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.8%

: 74-96-4
ethyl bromide

: 866624-79-5
3-bromo-4-(6-cyano-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester

: 866624-77-3
3-bromo-4-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester

Guidance literature:: 3-bromo-4-(6-cyano-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.166667 - 0.25h;

ethyl bromide; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; Product distribution / selectivity;

Reference yield: 75.0%

: 866624-79-5
3-bromo-4-(6-cyano-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester

: 75-03-6
ethyl iodide

: 866624-77-3
3-bromo-4-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester

Guidance literature:: 3-bromo-4-(6-cyano-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.25h;

ethyl iodide; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; Product distribution / selectivity;

Reference yield: 93.0%

: 787631-83-8
5-methyl-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid benzyl ester

: 866624-77-3
3-bromo-4-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-benzoic acid tert-butyl ester

: 6'-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-4-methyl-biphenyl-2,3'-dicarboxylic acid 2-benzyl ester 3'-tert-butyl ester

Guidance literature:: With tetrabutylammomium bromide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 95 ℃;