4-(2,6-difluoro-4-methoxyphenyl)-5-(4-ethynylphenyl)-3-methoxy-6-methylpyridazine

Base Information

Chemical Name:4-(2,6-difluoro-4-methoxyphenyl)-5-(4-ethynylphenyl)-3-methoxy-6-methylpyridazine
CAS No.:1321624-51-4
Molecular Formula:C₂₁H₁₆F₂N₂O₂
Molecular Weight:366.367
Hs Code.:

Synonyms:4-(2,6-difluoro-4-methoxyphenyl)-5-(4-ethynylphenyl)-3-methoxy-6-methylpyridazine

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Chemical Property of 4-(2,6-difluoro-4-methoxyphenyl)-5-(4-ethynylphenyl)-3-methoxy-6-methylpyridazine

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Technology Process of 4-(2,6-difluoro-4-methoxyphenyl)-5-(4-ethynylphenyl)-3-methoxy-6-methylpyridazine

There total 5 articles about 4-(2,6-difluoro-4-methoxyphenyl)-5-(4-ethynylphenyl)-3-methoxy-6-methylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1321624-42-3
3-chloro-5-(4-ethynylphenyl)-6-methyl-4-(2,4,6-trifluorophenyl)pyridazine

: 124-41-4
sodium methylate

: 1321624-51-4
4-(2,6-difluoro-4-methoxyphenyl)-5-(4-ethynylphenyl)-3-methoxy-6-methylpyridazine

Guidance literature:: In tetrahydrofuran; at 55 ℃; for 2h;

Reference yield:

: 10342-83-3
4'-Bromopropiophenone

: 1321624-51-4
4-(2,6-difluoro-4-methoxyphenyl)-5-(4-ethynylphenyl)-3-methoxy-6-methylpyridazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / Reflux

2.1: bromine / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: triethylamine / acetonitrile / 16 h / 20 °C

3.2: 1 h / Cooling

3.3: 1 h

4.1: hydrazine hydrate / butan-1-ol / 4 h / 120 °C

5.1: trichlorophosphate / 2 h / 110 °C

6.1: tetrahydrofuran / 2 h / 55 °C

With bromine; hydrazine hydrate; triethylamine; diisopropylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; acetonitrile; butan-1-ol;

Reference yield:

: 1321624-44-5
4-(4-ethynylphenyl)-5-hydroxy-5-methyl-3-(2,4,6-trifluorophenyl)-5H-furan-2-one

: 1321624-51-4
4-(2,6-difluoro-4-methoxyphenyl)-5-(4-ethynylphenyl)-3-methoxy-6-methylpyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / butan-1-ol / 4 h / 120 °C

2: trichlorophosphate / 2 h / 110 °C

3: tetrahydrofuran / 2 h / 55 °C

With hydrazine hydrate; trichlorophosphate; In tetrahydrofuran; butan-1-ol;