Iodoglibenclamide

Base Information

Chemical Name:Iodoglibenclamide
CAS No.:16789-77-8
Molecular Formula:C₂₃H₂₈IN₃O₅S
Molecular Weight:585.463
Hs Code.:
DSSTox Substance ID:DTXSID00937408
Nikkaji Number:J359.709A
Wikidata:Q82913630
ChEMBL ID:CHEMBL108053
Mol file:16789-77-8.mol

Synonyms:125I-iodoglibenclamide;iodoglibenclamide;LY 285110;LY-285110;N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-iodo-2-methoxybenzamide

Suppliers and Price of Iodoglibenclamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Iodoglibenclamide

Chemical Property:

Boiling Point:°Cat760mmHg
PKA:5.11±0.10(Predicted)
Flash Point:°C
PSA：121.98000
Density:1.57g/cm³
LogP:5.84640
XLogP3:4.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:585.07944
Heavy Atom Count:33
Complexity:746

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)I)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

Technology Process of Iodoglibenclamide

There total 5 articles about Iodoglibenclamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2786-00-7
2-methoxy-5-iodobenzoic acid

: 16789-77-8
[125I]-Iodoglibenclamide

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂

2: 2 N aq. sodium hydroxide

3: 1.) 1 N NaOH, 2.) potassium carbonate / 2.) acetone

With sodium hydroxide; thionyl chloride; potassium carbonate;
DOI:10.1021/jm00174a003

Reference yield:

: 40757-09-3
methyl 2-methoxy-5-iodobenzoate

: 16789-77-8
[125I]-Iodoglibenclamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2 N aq. NaOH

2: SOCl₂

3: 2 N aq. sodium hydroxide

4: 1.) 1 N NaOH, 2.) potassium carbonate / 2.) acetone

With sodium hydroxide; thionyl chloride; potassium carbonate;
DOI:10.1021/jm00174a003

Reference yield:

: 115860-69-0
2-methoxy-5-iodobenzoyl chloride

: 16789-77-8
[125I]-Iodoglibenclamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2 N aq. sodium hydroxide

2: 1.) 1 N NaOH, 2.) potassium carbonate / 2.) acetone

With sodium hydroxide; potassium carbonate;
DOI:10.1021/jm00174a003