3-fluorophenyl methane sulfonate

Base Information

• Chemical Name: 3-fluorophenyl methane sulfonate
• CAS No.: 57606-63-0
• Molecular Formula: C₇H₇FO₃S
• Molecular Weight: 190.195
• Mol file: 57606-63-0.mol

Synonyms:3-fluorophenyl methane sulfonate

Chemical Property of 3-fluorophenyl methane sulfonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-fluorophenyl methane sulfonate

There total 1 articles about 3-fluorophenyl methane sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanesulfonic acid (75-75-2,98527-29-8) + m-fluorophenyl benzoate (2714-92-3) → 3-fluorophenyl methane sulfonate (57606-63-0)

Guidance literature:

With phosphorus pentoxide; at 100 ℃; for 6h;

DOI:10.1080/10426500307808

Reference yield: 93.0%

3-fluorophenyl methane sulfonate (57606-63-0) + 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane (5123-13-7) → 3-fluorobiphenyl (2367-22-8)

Guidance literature:

With potassium phosphate tribasic hydrate; Ni^IICl(1-naphthyl)(tricyclohexylphosphine)₂; tricyclohexylphosphine; In tetrahydrofuran; at 23 ℃; for 1h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1055/s-0035-1562342

Reference yield: 85.0%

3-fluorophenyl methane sulfonate (57606-63-0) + phenylacetonitrile (140-29-4) → 2-(3-fluorophenyl)-2-phenylacetonitrile (164927-40-6)

Guidance literature:

With palladium diacetate; potassium carbonate; XPhos; In dichloromethane; tert-butyl alcohol; at 110 ℃; for 4h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/ejoc.202000176

upstream raw materials:

methanesulfonic acid

m-fluorophenyl benzoate

Downstream raw materials:

methyl 4-phenylbenzoate

3-fluorobiphenyl

2-(3-fluorophenyl)-2-phenylacetonitrile