2714-92-3

Basic information

• Product Name: 3-fluorophenyl benzoate
• CAS NO: 2714-92-3
• Molecular Formula: C₁₃H₉FO₂
• Molecular Weight: 216.2078
• Mol File: 2714-92-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 313.2°C at 760 mmHg
• Flash Point: 138.6°C
• Density: 1.221g/cm³
• Vapor Pressure: 0.000505mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 3-fluorophenyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluorophenyl benzoate(2714-92-3)
• EPA Substance Registry System: 3-fluorophenyl benzoate(2714-92-3)

Safety Data

• Hazardous Substances Data: 2714-92-3(Hazardous Substances Data)

Upstream product

• 1121-86-4 1-Fluoro-3-iodobenzene 
• 65-85-0 benzoic acid 
• 372-18-9 1,3-Difluorobenzene 
• 94-36-0 dibenzoyl peroxide 
• 372-20-3 3-fluorophenol 
• 98-88-4 benzoyl chloride 

Downstream Products

• 169781-83-3 (4-fluoro-2-hydroxyphenyl)(phenyl)methanone 
• 179018-59-8 [2-fluoro-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-phenyl-methanone 
• 179019-03-5 [2-fluoro-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-phenyl-methanol 
• 57606-63-0 3-fluorophenyl methane sulfonate 
• 179018-47-4 2-fluoro-4-hydroxybenzophenone 

Relevant articles and documents

Method for preparing carboxylate aryl type compound

The invention belongs to the field of drug synthesis and in particular relates to a method for preparing a carboxylate aryltype compound. The preparation method provided by the invention comprises thefollowing steps: providing a compound A of a formula a shown in the description, a compound B of a formula b shown in the description, an organic palladium complex, and a silver salt, wherein the organic palladium complex is composed of a palladium compound and a nitrogen-containing ligand; the nitrogen-containing ligand comprises an o-phenoline compound and/or a bipyridine compound; and mixing the compound A, the compound B, the organic palladium complex and the silver salt in a reaction solvent, and performing a reaction in an inert gas atmosphere, so as to obtain the carboxylate aryl typecompound of a formula I shown in the description. As the organic palladium complex and the silver salt are simultaneously used, direct selectivity C-O coupling of carboxylic acid and halogenated aromatic hydrocarbon is realized, and the method is applicable to a variety of carboxylic acid substrates and halogenated aromatic substrates, and is wide in compatibility and high in yield.

Systematic study of the luminescent europium-based nonanuclear clusters with modified 2-hydroxybenzophenone ligands

The reaction of 2-hydroxybenzophenone derivatives with europium ions has afforded a new family of luminescent nonanuclear Eu(III) clusters. Crystal structure analysis of the clusters reveals that the metal core comprises two vertex-sharing square pyramida

Structure-activity relationship studies on 1-[2-(4- phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A4 (LTA4) hydrolase

Leukotriene B4 (LTB4) is a pro-inflammatory mediator that has been implicated in the pathogenesis of a number of diseases including inflammatory bowel disease (IBD) and psoriasis. Since the action of LTA4 hydrolase is the rate-limiting step for LTB4 production, this enzyme represents an attractive pharmacological target for the suppression of LTB4 production. From an in- house screening program, SC-22716 (1, 1-[2-(4- phenylphenoxy)ethyl]pyrrolidine) was identified as a potent inhibitor of LTA4 hydrolase. Structure-activity relationship (SAR) studies around this structural class resulted in the identification of a number of novel, potent inhibitors of LTA4 hydrolase, several of which demonstrated good oral activity in a mouse ex vivo whole blood assay.