4-(4-methylaminocarbonyl-phenylamino)-piperidine-1-carboxylic acid benzyl ester hydrochloride

Base Information

Chemical Name:4-(4-methylaminocarbonyl-phenylamino)-piperidine-1-carboxylic acid benzyl ester hydrochloride
CAS No.:1037834-46-0
Molecular Formula:C₂₁H₂₅N₃O₃*ClH
Molecular Weight:403.909
Hs Code.:

Synonyms:4-(4-methylaminocarbonyl-phenylamino)-piperidine-1-carboxylic acid benzyl ester hydrochloride

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Chemical Property of 4-(4-methylaminocarbonyl-phenylamino)-piperidine-1-carboxylic acid benzyl ester hydrochloride

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Technology Process of 4-(4-methylaminocarbonyl-phenylamino)-piperidine-1-carboxylic acid benzyl ester hydrochloride

There total 1 articles about 4-(4-methylaminocarbonyl-phenylamino)-piperidine-1-carboxylic acid benzyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 6274-22-2
4-amino-N-methyl-benzamide

: 1037834-46-0
4-(4-methylaminocarbonyl-phenylamino)-piperidine-1-carboxylic acid benzyl ester hydrochloride

Guidance literature:: benzyl 4-oxo-1-piperidinecarboxylate; 4-amino-N-methyl-benzamide; With sodium tris(acetoxy)borohydride; acetic acid; In 1,1-dichloroethane; at 20 ℃; for 24h;

With sodium hydroxide; water; In 1,1-dichloroethane; pH=13;

With hydrogenchloride; In methanol; isopropyl alcohol; at 22 - 70 ℃; for 3h;

Reference yield: 100.0%

: 1037834-46-0
4-(4-methylaminocarbonyl-phenylamino)-piperidine-1-carboxylic acid benzyl ester hydrochloride

: 79-04-9
chloroacetyl chloride

: 1037834-47-1
4-[(2-chloro-acetyl)-(4-methylaminocarbonyl-phenyl)-amino]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: With pyridine; In ethyl acetate; at 15 - 25 ℃; for 3h;

Reference yield:

: 1037834-46-0
4-(4-methylaminocarbonyl-phenylamino)-piperidine-1-carboxylic acid benzyl ester hydrochloride

: 1037834-36-8
benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / ethyl acetate / 3 h / 15 - 25 °C

2: triethylamine / palladium diacetate; johnphos / 2-methyltetrahydrofuran; isopropyl alcohol / 23 h / 65 °C

With pyridine; triethylamine; palladium diacetate; johnphos; In 2-methyltetrahydrofuran; ethyl acetate; isopropyl alcohol;