benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate
CAS No.:1037834-36-8
Molecular Formula:C₂₃H₂₅N₃O₄
Molecular Weight:407.469
Hs Code.:

Synonyms:benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate

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Chemical Property of benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate

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Technology Process of benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate

There total 14 articles about benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1037834-35-7
1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-2-oxoindoline-5-carboxylic acid

: 74-89-5
methylamine

: 1037834-36-8
benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate

Guidance literature:: 1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-2-oxoindoline-5-carboxylic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; at 20 ℃; for 1h;

methylamine; In tetrahydrofuran; acetonitrile; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield: 60.0%

: 1037834-47-1
4-[(2-chloro-acetyl)-(4-methylaminocarbonyl-phenyl)-amino]-piperidine-1-carboxylic acid benzyl ester

: 1037834-36-8
benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate

Guidance literature:: With triethylamine; palladium diacetate; johnphos; In 2-methyltetrahydrofuran; isopropyl alcohol; at 65 ℃; for 23h; Product distribution / selectivity;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1037834-36-8
benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / 1,1-dichloroethane / 24 h / 20 °C

1.2: pH 13

1.3: 3 h / 22 - 70 °C

2.1: pyridine / ethyl acetate / 3 h / 15 - 25 °C

3.1: triethylamine / palladium diacetate; johnphos / 2-methyltetrahydrofuran; isopropyl alcohol / 23 h / 65 °C

With pyridine; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; palladium diacetate; johnphos; In 2-methyltetrahydrofuran; 1,1-dichloroethane; ethyl acetate; isopropyl alcohol;