N-(benzyloxycarbonyl)-(RS)-2-aminomalonic acid (tert-butyloxycarbonyl)hydrazidyl benzyl ester

Base Information

Chemical Name:N-(benzyloxycarbonyl)-(RS)-2-aminomalonic acid (tert-butyloxycarbonyl)hydrazidyl benzyl ester
CAS No.:72594-96-8
Molecular Formula:C₂₃H₂₇N₃O₇
Molecular Weight:457.483
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)-(RS)-2-aminomalonic acid (tert-butyloxycarbonyl)hydrazidyl benzyl ester

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Chemical Property of N-(benzyloxycarbonyl)-(RS)-2-aminomalonic acid (tert-butyloxycarbonyl)hydrazidyl benzyl ester

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Technology Process of N-(benzyloxycarbonyl)-(RS)-2-aminomalonic acid (tert-butyloxycarbonyl)hydrazidyl benzyl ester

There total 4 articles about N-(benzyloxycarbonyl)-(RS)-2-aminomalonic acid (tert-butyloxycarbonyl)hydrazidyl benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 870-46-2
t-butoxycarbonylhydrazine

: 40204-01-1
N-(benzyloxycarbonyl)-(RS)-2-aminomalonic acid benzyl ester

: 72594-96-8
N-(benzyloxycarbonyl)-(RS)-2-aminomalonic acid (tert-butyloxycarbonyl)hydrazidyl benzyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In ethyl acetate; for 12h; Ambient temperature;
DOI:10.1021/jm00178a012

Reference yield:

: 15014-25-2
malonic acid dibenzyl ester

: 72594-96-8
N-(benzyloxycarbonyl)-(RS)-2-aminomalonic acid (tert-butyloxycarbonyl)hydrazidyl benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 40percentaq. AcOH, NaNO₃, 2.) Al(Hg), H₂O / 1.) 1,4-dioxane, 2.5 h, 2.) THF, reflux, 1 h

2: sat. aq. NaHCO₃ / 12 h / Ambient temperature

3: 58 percent / LiOH*H₂O / acetone; H₂O / 12 h / Ambient temperature

4: 91 percent / DCC / ethyl acetate / 12 h / Ambient temperature

With lithium hydroxide; sodium nitrate; aluminum amalgam; water; sodium hydrogencarbonate; acetic acid; dicyclohexyl-carbodiimide; In water; ethyl acetate; acetone;
DOI:10.1021/jm00178a012

Reference yield:

: 31661-15-1
dibenzyl aminomalonate

: 72594-96-8
N-(benzyloxycarbonyl)-(RS)-2-aminomalonic acid (tert-butyloxycarbonyl)hydrazidyl benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sat. aq. NaHCO₃ / 12 h / Ambient temperature

2: 58 percent / LiOH*H₂O / acetone; H₂O / 12 h / Ambient temperature

3: 91 percent / DCC / ethyl acetate / 12 h / Ambient temperature

With lithium hydroxide; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In water; ethyl acetate; acetone;
DOI:10.1021/jm00178a012