3(R),4-dimethyl-4(R)-(3-trifluoromethanesulfonyloxyphenyl)-1-tert-butyloxycarbonylpiperidine

Base Information

Chemical Name:3(R),4-dimethyl-4(R)-(3-trifluoromethanesulfonyloxyphenyl)-1-tert-butyloxycarbonylpiperidine
CAS No.:762299-36-5
Molecular Formula:C₁₉H₂₆F₃NO₅S
Molecular Weight:437.48
Hs Code.:

Synonyms:3(R),4-dimethyl-4(R)-(3-trifluoromethanesulfonyloxyphenyl)-1-tert-butyloxycarbonylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3(R),4-dimethyl-4(R)-(3-trifluoromethanesulfonyloxyphenyl)-1-tert-butyloxycarbonylpiperidine

Chemical Property:

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Technology Process of 3(R),4-dimethyl-4(R)-(3-trifluoromethanesulfonyloxyphenyl)-1-tert-butyloxycarbonylpiperidine

There total 3 articles about 3(R),4-dimethyl-4(R)-(3-trifluoromethanesulfonyloxyphenyl)-1-tert-butyloxycarbonylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 205999-74-2
4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-tert-butyloxycarbonylpiperidine

: 762299-36-5
3(R),4-dimethyl-4(R)-(3-trifluoromethanesulfonyloxyphenyl)-1-tert-butyloxycarbonylpiperidine

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃;
DOI:10.1016/j.bmcl.2003.09.012

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 762299-36-5
3(R),4-dimethyl-4(R)-(3-trifluoromethanesulfonyloxyphenyl)-1-tert-butyloxycarbonylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Et₃N / tetrahydrofuran / 25 °C

2: 74 percent / Et₃N / CH₂Cl₂ / 25 °C

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2003.09.012

Reference yield:

: 119193-19-0
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

: 762299-36-5
3(R),4-dimethyl-4(R)-(3-trifluoromethanesulfonyloxyphenyl)-1-tert-butyloxycarbonylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Et₃N / tetrahydrofuran / 25 °C

2: 74 percent / Et₃N / CH₂Cl₂ / 25 °C

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2003.09.012