N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(trifluoromethyl)phenyl)-2,2-dimethylpropanamide

Base Information

Chemical Name:N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(trifluoromethyl)phenyl)-2,2-dimethylpropanamide
CAS No.:1334531-17-7
Molecular Formula:C₂₀H₂₁ClF₃NO₃
Molecular Weight:415.84
Hs Code.:

Synonyms:N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(trifluoromethyl)phenyl)-2,2-dimethylpropanamide

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Chemical Property of N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(trifluoromethyl)phenyl)-2,2-dimethylpropanamide

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Technology Process of N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(trifluoromethyl)phenyl)-2,2-dimethylpropanamide

There total 3 articles about N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(trifluoromethyl)phenyl)-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1007652-06-3
N-[4-chloro-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide

: 135-02-4
ortho-anisaldehyde

: 1334531-17-7
N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(trifluoromethyl)phenyl)-2,2-dimethylpropanamide

Guidance literature:: N-[4-chloro-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide; With sec.-butyllithium; In tetrahydrofuran; hexane; cyclohexane; at -78 - 20 ℃; for 0.5h;

ortho-anisaldehyde; In tetrahydrofuran; hexane; cyclohexane; at -78 - -50 ℃; for 1.5h;

With water; ammonium chloride; In tetrahydrofuran; hexane; cyclohexane; ethyl acetate;
DOI:10.1016/j.bmc.2011.07.007

Reference yield:

: 445-03-4
4-chloro-2-(trifluoromethyl)aniline

: 1334531-17-7
N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(trifluoromethyl)phenyl)-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 16 h / 0 - 20 °C

2.1: sec.-butyllithium / tetrahydrofuran; hexane; cyclohexane / 0.5 h / -78 - 20 °C

2.2: 1.5 h / -78 - -50 °C

With dmap; sec.-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane; cyclohexane;
DOI:10.1016/j.bmc.2011.07.007

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1334531-17-7
N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(trifluoromethyl)phenyl)-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 16 h / 0 - 20 °C

2.1: sec.-butyllithium / tetrahydrofuran; hexane; cyclohexane / 0.5 h / -78 - 20 °C

2.2: 1.5 h / -78 - -50 °C

With dmap; sec.-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane; cyclohexane;
DOI:10.1016/j.bmc.2011.07.007