N-[2-(4'-methylbenzenesulfonamido)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine

Base Information

• Chemical Name: N-[2-(4'-methylbenzenesulfonamido)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine
• CAS No.: 1426922-36-2
• Molecular Formula: C₂₂H₂₂N₂O₄S₂
• Molecular Weight: 442.56
• Mol file: 1426922-36-2.mol

Synonyms:N-[2-(4'-methylbenzenesulfonamido)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine

Chemical Property of N-[2-(4'-methylbenzenesulfonamido)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(4'-methylbenzenesulfonamido)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine

There total 2 articles about N-[2-(4'-methylbenzenesulfonamido)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-toluenesulfonyl azide (941-55-9) + 3-methyl-N-(methyl(oxo)(phenyl)-λ6-sulfanylidene)benzamide (1377585-41-5) → N-[2-(4'-methylbenzenesulfonamido)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine (1426922-36-2)

Guidance literature:

With silver hexafluoroantimonate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; potassium acetate; In 1,2-dichloro-ethane; at 120 ℃; for 24h; Solvent; Temperature; Reagent/catalyst; regioselective reaction; Schlenk technique; Glovebox;

DOI:10.1021/ol400411v

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N-[2-(4'-methylbenzenesulfonamido)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine (1426922-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / water; acetone / 0 - 20 °C / Schlenk technique

2: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; potassium acetate; silver hexafluoroantimonate / 1,2-dichloro-ethane / 24 h / 120 °C / Schlenk technique; Glovebox

With silver hexafluoroantimonate; sodium azide; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; potassium acetate; In water; 1,2-dichloro-ethane; acetone;

DOI:10.1021/ol400411v

Reference yield: 89.0%

N-[2-(4'-methylbenzenesulfonamido)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine (1426922-36-2) → 5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid (34161-81-4) + S-methyl-S-phenylsulfoximine (4381-25-3)

Guidance literature:

With water; sodium hydroxide; In methanol; at 60 ℃; for 6h; Schlenk technique;

DOI:10.1021/ol400411v

upstream raw materials:

4-toluenesulfonyl azide

3-methyl-N-(methyl(oxo)(phenyl)-λ⁶-sulfanylidene)benzamide

p-toluenesulfonyl chloride

Downstream raw materials:

5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid

S-methyl-S-phenylsulfoximine